Extract of Woodfordia fruticosa flowers ameliorates hyperglycemia, oxidative stress and improves β-cell function in streptozotocin-nicotinamide induced diabetic rats

Journal of Ethnopharmacology
Aditya AryaHapipah Mohd Ali

Abstract

The art of Ayurveda and the traditional healing system in India have reflected the ethnomedicinal importance of the plant Woodfordia fruticosa Kurtz, which demonstrates its vast usage in the Ayurvedic preparations as well as in the management of diabetes by the traditional healers. The study aimed to ascertain the antidiabetic potential of W. fruticosa flower methanolic extract (WF) on Streptozotocin (STZ)-nicotinamide-induced diabetic rat model. Diabetes was induced in Sprague Dawley (SD) rats by STZ-nicotinamide and thereafter diabetic rats were treated with three different doses of WF (100, 200 and 400mg/kg body weight) respectively and glibenclamide as a positive control. Biochemical parameters such as blood glucose, serum insulin and C-peptide levels were measured with oxidative stress markers. Furthermore, histology of liver and pancreas was carried out to evaluate glycogen content and β-cell structures. Moreover, immunohistochemistry and western blot analysis were performed on kidney and pancreas tissues to determine renal Bcl-2, pancreatic insulin and glucose transporter (GLUT-2, 4) protein expression in all the experimental groups. The acute toxicity study showed non-toxic nature of all the three doses of WF. Further, ...Continue Reading

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Citations

Feb 1, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Abu Sadat Md SayemChowdhury Faiz Hossain
Nov 11, 2015·The Korean Journal of Internal Medicine·Sun Woo LimCan Li
Oct 2, 2020·Chinese Journal of Integrative Medicine·Hui ShenHai-Cheng Zhou
Feb 7, 2019·Pakistan Journal of Biological Sciences : PJBS·Younis Ahmad HajamSrishti Singh
Sep 20, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Suhair A AbdellatiefShefaa A M El-Mandrawy
Aug 3, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Akurange Sujeevi Dammadinna WickramasingheAnoja Priyadarshani Attanayake

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