Jan 28, 1999

Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints

Statistics in Medicine
M K ParmarL Stewart

Abstract

Meta-analyses aim to provide a full and comprehensive summary of related studies which have addressed a similar question. When the studies involve time to event (survival-type) data the most appropriate statistics to use are the log hazard ratio and its variance. However, these are not always explicitly presented for each study. In this paper a number of methods of extracting estimates of these statistics in a variety of situations are presented. Use of these methods should improve the efficiency and reliability of meta-analyses of the published literature with survival-type endpoints.

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Mentioned in this Paper

Controlled Clinical Trials, Randomized
Survival Analysis
Cox Proportional Hazards Models
Meta Analysis (Statistical Procedure)

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