Extraction and microencapsulation of khat: effects on sexual motivation and estradiol level in female rats

The Journal of Sexual Medicine
Hesham Abdul AzizYvonne Tze Fung Tan

Abstract

Khat (Catha edulis) is an evergreen tree/shrub that is thought to affect sexual motivation or libido. Its positive effect on sexual desire is more frequently observed in females than in males and occurs when khat is chewed. Thus, khat's effects on sexual behavior may depend on the release mode of its active constituent. This study aimed to investigate the effect of dried khat alkaloids on the sexual motivation and estradiol levels of female rats, with special emphasis on the importance of the sustained release effect. Dried khat leaves were extracted and isolated. The alkaloids in khat extract were identified and calculated using thin layer chromatography and high-performance liquid chromatography. The isolated khat extract was microencapsulated using a phase separation coacervation method. The morphology, particle size, yield, drug loading, and entrapment efficiency were evaluated. The in vitro release and stability of alkaloids in khat extract and in khat extract microcapsules were determined. The effect of khat extract microcapsules and varying doses of khat extract on sexual motivation in female rats were investigated. Additionally, estradiol levels, vaginal secretions and vaginal pH were determined. The differences in the ...Continue Reading

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Citations

Sep 20, 2012·Culture, Health & Sexuality·Della BerhanuTewabech Bishaw
Oct 1, 2011·Obesity Research & Clinical Practice·Hesham Abdul AzizYvonne Tze Fung Tan
Oct 1, 2010·Obesity Research & Clinical Practice·Hesham Abdul AzizMun Fei Yam
Nov 9, 2011·Journal of Ethnopharmacology·Craig MurdochMunitta Muthana
Mar 21, 2017·Frontiers in Neurology·Elham A AfifyLateef M Khan
May 28, 2013·International Journal of Molecular Medicine·Morad Dirhem Naji AbidFeili Gong
Jul 31, 2020·Journal of Ethnopharmacology·Mustafa Ahmed AlshaggaMohammed Abdullah Alshawsh

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