PMID: 9553834Apr 29, 1998Paper

Extraction, assay, and analysis of antimicrobials from plants with activity against dental pathogens (Streptococcus sp.)

The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy
J Tichy, J Novak

Abstract

Many dental and periodontal diseases are largely a question of bacterial etiology. Dental caries develop due to an increase of strongly acidogenic and aciduric gram-positive bacteria while common forms of periodontal disease are linked to anaerobic gram-negative bacteria in subgingival plaque. Many plants and plant-derived antimicrobial components are used in folklore therapeutics for the treatment of periodontal disorders and for the purposes of oral hygiene. Some have been evaluated for possible use in modern medicine, while thousands of other potentially useful/plants have not been tested. In this study, we evaluated the feasibility of screening for antibacterials isolated from plants with activity against three representatives of oral streptococci. We developed and tested the following methodologies: (1) Extraction of antibacterial components from plants; (2) Assays for antibacterial activity; (3) Chromatographic methods for initial analysis of compounds of interest. The screening process for plant antimicrobials consisted of extraction of plant material and assay of antibacterial activity using a spotting test with the selected oral streptococci as indicator strains. In addition, we developed chromatographic procedures tha...Continue Reading

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Citations

Nov 4, 2000·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·J Tichy, J Novak
Mar 7, 2014·Pharmacognosy Reviews·Nilesh Arjun TorwaneB R Chandrashekar
Mar 23, 2012·Pharmacognosy Magazine·Kathleen A GibsonYulin Ren
Aug 7, 2014·Journal of Natural Science, Biology, and Medicine·Maji JoseManjula Shantaram
Feb 16, 2008·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·L S B AlmeidaP L Rosalen
Jul 4, 2012·Journal of Applied Microbiology·J SmullenH A Foster
Oct 27, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Michael Ashu Agbor, Sudeshni Naidoo
Aug 21, 2012·The Journal of Clinical Pediatric Dentistry·Y RamakrishnaA K Munshi
Jun 14, 2019·Environmental Science and Pollution Research International·Varsha TripathiNatesan Manickam

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