Extraction, identification, fractionation and isolation of phenolic compounds in plants with hepatoprotective effects

Journal of the Science of Food and Agriculture
Carla PereiraIsabel C F R Ferreira

Abstract

The liver is one of the most important organs of human body, being involved in several vital functions and regulation of physiological processes. Given its pivotal role in the excretion of waste metabolites and drugs detoxification, the liver is often subjected to oxidative stress that leads to lipid peroxidation and severe cellular damage. The conventional treatments of liver diseases such as cirrhosis, fatty liver and chronic hepatitis are frequently inadequate due to side effects caused by hepatotoxic chemical drugs. To overcome this problematic paradox, medicinal plants, owing to their natural richness in phenolic compounds, have been intensively exploited concerning their extracts and fraction composition in order to find bioactive compounds that could be isolated and applied in the treatment of liver ailments. The present review aimed to collect the main results of recent studies carried out in this field and systematize the information for a better understanding of the hepatoprotective capacity of medicinal plants in in vitro and in vivo systems. Generally, the assessed plant extracts revealed good hepatoprotective properties, justifying the fractionation and further isolation of phenolic compounds from different parts o...Continue Reading

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Citations

Jul 27, 2017·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Liang WangFei Chen
May 6, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fedia SouilemIsabel C F R Ferreira
Aug 31, 2019·Food & Function·Cristina CalejaIsabel C F R Ferreira
Jan 2, 2019·JAD Reports·Steffi WitterAgo Samoson
Apr 16, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Mazin A ZamzamiMohamed Kamel Abo-Golayel
Mar 1, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Elena Roselló-SotoFrancisco J Barba
Sep 27, 2020·The Journal of Pharmacy and Pharmacology·Zhipeng WangXiaohui Chen
Dec 31, 2019·Journal of Alzheimer's Disease : JAD·Steffi WitterRaiker Witter
Dec 23, 2020·Journal of Food Biochemistry·Seham S El-HawaryRania A El Gedaily
May 1, 2017·Comprehensive Reviews in Food Science and Food Safety·Ezgi Doğan Cömert, Vural Gökmen
Jul 20, 2021·Critical Reviews in Food Science and Nutrition·Priyanka ChopraRavi Gupta

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