Extraction of astaxanthin from microalga Haematococcus pluvialis in red phase by using generally recognized as safe solvents and accelerated extraction

Journal of Biotechnology
Antonio MolinoDino Musmarra

Abstract

Solvent Extraction was tested to extract astaxanthin from Haematococcus pluvialis in red phase (HPR), by investigating effects of solvents, extraction pressure and temperature. Astaxanthin isomers were identified and quantified in the extract. The performances of acetone and ethanol, Generally Recognized As Safe (GRAS) solvents, were explored. Negligible effect of pressure was found, while with increasing extraction temperature astaxanthin recovery increased till a maximum value, beyond which thermal degradation seemed to be greater than the positive effect of temperature on extraction. Furthermore, to maximize the extraction yield of astaxanthin, mechanical pre-treatment of HPR biomass was carried out and several extraction runs were consecutively performed. Experimental results showed that after the mechanical pre-treatment the astaxanthin recovery strongly increased while a single extraction run of 20 min was sufficient to extract more than 99% of total astaxanthin extracted. After pre-treatment, maximum recovery of about 87% was found for acetone (pressure = 100 bar; temperature = 40 °C; total time = 60 min).

Citations

Jul 3, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gian Paolo LeoneAntonio Molino
Nov 6, 2018·International Journal of Environmental Research and Public Health·Antonio MolinoDino Musmarra
Feb 24, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Antonio MolinoDino Musmarra
May 14, 2020·Applied Microbiology and Biotechnology·Congqiang ZhangHeng-Phon Too
Sep 10, 2020·Frontiers in Bioengineering and Biotechnology·Diederich Aguilar-MachadoJavier Raso
Apr 17, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sanjeet MehariyaAntonio Molino
Nov 14, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mari Carmen Ruiz-DomínguezPedro Cerezal
Nov 23, 2019·Applied Biochemistry and Biotechnology·Ji-Yeon ParkMin-Cheol Kim
Feb 14, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Vimala BalasubramaniamMohd Fairulnizal Mohd Noh
Jan 13, 2021·Marine Drugs·Mariano CatanesiAnnamaria Cimini
Apr 10, 2020·Biotechnology Advances·Wendie LevasseurVictor Pozzobon
Oct 17, 2020·Journal of the Science of Food and Agriculture·Lu YangChanghu Xue
Apr 4, 2021·Marine Drugs·Antia G PereiraMiguel A Prieto
Jun 3, 2021·Marine Drugs·Fabian SandgruberChristine Dawczynski
Jun 15, 2021·Saudi Journal of Biological Sciences·Cid-Pérez Teresa SoledadÁvila-Sosa Raúl
Jul 15, 2021·Biotechnology Reports·Rosa Paola RadiceGiuseppe Martelli

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