Extraction of curcuminoids by using ethyl lactate and its optimisation by response surface methodology

Journal of Pharmaceutical and Biomedical Analysis
Angelo Antonio D'ArchivioFabrizio Ruggieri

Abstract

Response surface methodology (RSM) was applied to optimise the extraction of curcuminoids (curcumin, demethoxycurcumin and bisdemethoxycurcumin) from turmeric using ethyl lactate (EL), ethanol and water under mild conditions (magnetic stirring at room temperature). An augmented simplex-centroid mixture design was used to monitor the dependence of the extraction efficiency from the proportions of the three solvents in the extraction medium. HPLC was used to establish the content of curcuminoids in turmeric and in the extracts. Surface plots for the extracted amount of each curcuminoid covering the whole composition domain were generated by interpolation of the experimental data with quadratic canonical polynomial models. The response surfaces of the three curcuminoids are qualitatively similar and the maximum extraction efficiency was obtained with water-EL 30:70v/v that ensured the almost quantitative recovery of the three compounds from turmeric. While degradation of the three curcuminoids in water at moderate alkaline pH is relatively fast (half-times are between 0.23 and 8.5h at pH=8.6), their stability is noticeably greater in EL (half-times are within 21-69days). Addition of EL to water is also able to inhibit the alkaline...Continue Reading

Citations

Aug 23, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Farid ChematAnne-Sylvie Fabiano Tixier
Dec 17, 2020·Comprehensive Reviews in Food Science and Food Safety·Leonardo M de Souza MesquitaVeridiana V de Rosso
Dec 26, 2018·International Journal of Biological Macromolecules·Bianca C Maniglia, Delia R Tapia-Blácido

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