Extraction of saponins and toxicological profile of Teucrium stocksianum boiss extracts collected from District Swat, Pakistan

Biological Research
Syed Muhammad Mukarram ShahShahzeb Khan

Abstract

The current era is facing challenges in the management of neoplasia and weeds control. The currently available anti-cancer and herbicidal drugs are associated with some serious side effects. Therefore numerous researchers are trying to discover and develop plant based alternative particularly for the rational management of cancer and weed control. Teucrium stocksianum possess antioxidant and analgesic activities. The current study was designed to evaluate crude saponins (CS), methanolic extract and sub-fractions of T. stocksianum for cytotoxic and phytotoxic potentials. CS, methanolic extract and sub-fractions were extracted from powdered plant material using different solvents. Cytotoxic potential of the extracts at a dose of 10, 100 and 1000 μg/ml were evaluated against Brine shrimp's nauplii. Phytotoxic assay also performed at the same concentration against Lemna minor. Etoposide and Paraquat were used as positive controls in cytotoxic and phytotoxic assays respectively. The percent yield of crude saponins was (5%). CS demonstrated tremendous brine shrimp lethality showing < 10 μg/ml LC50. The n-hexane (HF) and chloroform fractions (CF) demonstrated excellent cytotoxicity with 80 and 55 μg/ml LC50 respectively. Whereas the m...Continue Reading

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Citations

Oct 9, 2015·BMC Complementary and Alternative Medicine·Syed Muhammad Mukarram Shah, Syed Muhammad Hassan Shah
Sep 1, 2015·BMC Complementary and Alternative Medicine·Syed Muhammad Mukarram Shah
Jul 2, 2016·Pharmacognosy Research·Raju DashMir Muhammad Nasir Uddin
Nov 25, 2017·BMC Complementary and Alternative Medicine·Muhammad ImranFarman Ullah
Jul 6, 2019·Frontiers in Pharmacology·Lee Yen SimKhairana Husain
Jan 7, 2022·Natural Product Research·Zahra SadeghiMahdi Moridi Farimani

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