Extractions of isoquinoline alkaloids with butanol and octanol

Fitoterapia
Jana GregorovaJirí Dostál

Abstract

Six different isoquinoline alkaloids (sanguinarine, chelerythrine, berberine, coptisine, allocryptopine, and protopine) were extracted by butanol and octanol from aqueous solution, pH 4.5. The samples were analyzed by HPLC. Butanol extraction was non-selective, alkaloids passed into organic phase in 83-98%. Octanol extraction provided more selective yields: sanguinarine 99%, chelerythrine 94%, berberine 18%, coptisine 16%, allocryptopine 7.5%, protopine 7%. Further, we tested octanol treatment of extract from Dicranostigma lactucoides. The octanol extraction yields were also selective: sanguinarine 98%, chelerythrine 92%, chelirubine 92.5%, protopine 6% and allocryptopine 3.5%. 6-Butoxy-5,6-dihydrosanguinarine and 6-butoxy-5,6-dihydrochelerythrine were prepared and their NMR and MS data are reported and discussed.

References

Apr 26, 2003·Journal of Natural Products·Radek MarekVladimír Sklenár
May 11, 2005·Magnetic Resonance in Chemistry : MRC·Jaromír TousekRadek Marek
Mar 21, 2007·Journal of Pharmaceutical and Biomedical Analysis·Jana SuchomelováEva Táborská
Jun 6, 2007·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Iva SlaninováEva Táborská

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Citations

Apr 23, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kristýna PěnčíkováJana Gregorová

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