Sep 30, 2008

Extractive spectrophotometric determination of TRODAT-1 hydrochloride in lyophilized kit

Die Pharmazie
X M LiM F Zou

Abstract

A simple, sensitive, and accurate spectrophotometric method has been developed for the assay of TRODAT-1 hydrochloride in lyophilized kit. The method is based on the formation of ion-pair association complex of TRODAT-1 with bromothymol blue (BTB) in disodium hydrogen phosphate/citric acid buffer of pH 4.0. The colored product was extracted with chloroform, and measured spectrophotometrically at 414 nm. Beer's law was obeyed in the range of 5-25 microg/ml with molar absorptivity of 2.75 x 10(4) l/mol/cm. Optimization of experimental conditions was described for the method. The proposed method has been successfully applied for the analysis of TRODAT-1 hydrochloride in lyophilized kit. No interference with pharmaceutical excipients was observed.

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Mentioned in this Paper

Citricum acidum, citric acid, homeopathic preparation
Azabicyclo(3.2.1)Octanes
Sodium Phosphate, Dibasic
Technetium Tc 99m TRODAT-1
Spectrophotometry, Ultraviolet
Bromthymol Blue
Molar Tooth
Freeze Drying
Organic Pigments
Assay

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