Extracts from two frequently consumed spices--cumin (Cuminum cyminum) and turmeric (Curcuma longa)--inhibit platelet aggregation and alter eicosanoid biosynthesis in human blood platelets

Prostaglandins, Leukotrienes, and Essential Fatty Acids
K C Srivastava

Abstract

In the traditional Indian system of medicine, Ayurveda, several spices and herbs are claimed to possess medicinal properties, such as being antithrombotic, antiatherosclerotic, hypolipidemic, anti-inflammatory etc. Earlier we have reported that extracts from several spices behave as antiaggregatory agents and inhibit eicosanoid synthesis. Similar studies with extracts prepared from cumin (Cuminum cyminum) and turmeric (Curcuma longa) were undertaken. Ethereal extract of both cumin and turmeric inhibited arachidonate-induced platelet aggregation. Extracts from these spices inhibited thromboxane B2 production from exogenous (14C) arachidonic acid (AA) in washed platelets; a simultaneous increase in the formation of lipoxygenase-derived products was observed. Less TxB2 was produced in blood samples treated with turmeric extract when they were allowed to clot. Turmeric extract inhibited incorporation of (14C)AA into platelet phospholipids and deacylation of AA-labelled phospholipids on stimulation with calcium ionophore A23187. Cumin extract was devoid of such effects. Extracts from the two spices reduced the formation of (14C)TxB2 from AA-labelled platelets when they were challenged with A23187. The anti-inflammatory property of t...Continue Reading

References

May 1, 1989·Medical Hypotheses·K C Srivastava, T Mustafa
Mar 1, 1989·Prostaglandins, Leukotrienes, and Essential Fatty Acids·K C Srivastava
Jun 1, 1986·Prostaglandins, Leukotrienes, and Medicine·K C Srivastava
Sep 1, 1986·Prostaglandins, Leukotrienes, and Medicine·K C Srivastava
Dec 1, 1986·Prostaglandins, Leukotrienes, and Medicine·K C Srivastava
Jan 1, 1988·Acta Oto-laryngologica·A GrøntvedE Hentzer
May 1, 1988·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·S I Rattan
Oct 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·M HambergB Samuelsson
Mar 20, 1982·Lancet·D B Mowrey, D E Clayson
Aug 1, 1983·Carcinogenesis·S Belman
Jan 23, 1982·The Medical Journal of Australia·G E Rich
Sep 25, 1980·The New England Journal of Medicine·T O Cheng

❮ Previous
Next ❯

Citations

Jan 3, 1991·The New England Journal of Medicine·J N George, S J Shattil
Oct 6, 2012·Critical Reviews in Food Science and Nutrition·H B Sowbhagya
Nov 19, 2011·Pharmacognosy Reviews·R K Johri
Aug 2, 2007·Hematology/oncology Clinics of North America·Yu-Min P Shen, Eugene P Frenkel
Oct 13, 2015·Journal of Ethnopharmacology·Farzaneh Shakeri, Mohammad Hossein Boskabady
Dec 1, 1989·Prostaglandins, Leukotrienes, and Essential Fatty Acids·K C Srivastava, T Mustafa
May 1, 1993·Prostaglandins, Leukotrienes, and Essential Fatty Acids·K C Srivastava
Mar 19, 2013·Biochemical Pharmacology·Jorge L M RuizSérgio P Bydlowski
Mar 2, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mario Pulido-MoranMcarmen Ramirez-Tortosa
Jun 21, 2002·Asia Pacific Journal of Clinical Nutrition·Rajagopal Senthil KumarNamasivayam Nalini
Apr 18, 2020·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Jonathan de GrégoriMathieu Boulin
Oct 8, 2020·Operative Neurosurgery·Kayceety MullajAmala Guha
Feb 1, 2020·Bulletin du cancer·Soumaya LabidiHamouda Boussen
Apr 17, 2021·Hämostaseologie·Carlo Zaninetti, Thomas Thiele

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.