Extracts of Glycyrrhiza uralensis and isoliquiritigenin counteract amyloid-β toxicity in Caenorhabditis elegans

Planta medica
Pille LinkMichael Wink

Abstract

Alzheimer's disease is a rising threat for modern societies as more and more people reach old age. To date, there is no effective treatment for this condition. In this study, we investigated the potential of Glycyrrhiza uralensis to counteract amyloid-β toxicity, one of the key features of Alzheimer's disease. An LC-MS/MS analysis revealed glycyrrhizic acid and glycosylated forms of isoliquiritigenin and liquiritigenin as major constituents of water and methanol extracts of G. uralensis. These extracts and the pure compounds were tested for their activity in two Caenorhabditis elegans models of amyloid-β aggregation and amyloid-β toxicity, respectively. The number of amyloid-β aggregates decreased by 30% after treatment with isoliquiritigenin, the methanol extract could reduce the number by 14%, liquiritigenin and glycyrrhizic acid by 15%, and the aglycon of glycyrrhizic acid, glycyrrhetinic acid, by 20%. Both extracts and isoliquiritigenin also showed significant activity against acute amyloid-β toxicity in transgenic C. elegans that express human amyloid-β peptides, delaying the paralysis in this model by 1.8 h and 1.1 h, respectively. We conclude that secondary compounds of G. uralensis may become interesting drug candidates...Continue Reading

Citations

Aug 16, 2016·Archives of Pharmacal Research·Doo Sin JoDong-Hyung Cho
Nov 4, 2017·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Qun ZhaoLichun Feng
Feb 20, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fangzhou DuXueqi Fu
Sep 15, 2020·Journal of Biochemical and Molecular Toxicology·Dicson Sheeja MalarKasi Pandima Devi
Jul 8, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Pille LinkMichael Wink
Aug 23, 2019·Aging and Disease·Seong Gak JeonMinho Moon

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