Extracytoplasmic prosthetic group ligation to apoproteins: maturation of c-type cytochromes.

Molecular Microbiology
Serdar TurkarslanFevzi Daldal

Abstract

In all organisms, haem is post-translationally and covalently attached to c apocytochromes to produce c holocytochromes via a process called c-type cytochromes maturation, which involves numerous components. In bacteria it was not clear which of these components catalyses the extracytoplasmic haem-apocytochrome ligation per se. In this issue of Molecular Microbiology, Feissner and colleagues report that a single polypeptide from Helicobacter pylori, corresponding to the fusion of two proteins found in other organisms, performs haem ligation to a coexpressed Bordetella pertussis apocytochrome c in an Escherichia coli mutant lacking its own cytochrome c maturation proteins. This simple experimental system pinpoints the components catalysing extracytoplasmic covalent haem ligation and raises intriguing issues about the requirements for delivery of haem and apocytochrome c substrates to produce c holocytochromes.

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Citations

Jun 11, 2009·Proceedings of the National Academy of Sciences of the United States of America·Elaine R Frawley, Robert G Kranz
Jun 23, 2009·Proceedings of the National Academy of Sciences of the United States of America·Sabeeha S Merchant
Oct 30, 2009·The Journal of Biological Chemistry·Michaela KupkaKai-Hong Zhao
Sep 2, 2009·Microbiology and Molecular Biology Reviews : MMBR·Robert G KranzElaine R Frawley
Aug 30, 2007·Proceedings of the National Academy of Sciences of the United States of America·Kai-Hong ZhaoHugo Scheer
Apr 13, 2010·Trends in Microbiology·Carsten SandersFevzi Daldal
Nov 24, 2007·Mitochondrion·P GiegéG Bonnard
Feb 21, 2008·Molecular Microbiology·H Scheer, K-H Zhao
Jul 6, 2010·Journal of Molecular Biology·Cynthia Richard-Fogal, Robert G Kranz
Sep 29, 2011·Biochimica Et Biophysica Acta·Cynthia L Richard-FogalRobert G Kranz
Jul 12, 2007·The Journal of Biological Chemistry·Adele Di MatteoCarlo Travaglini-Allocatelli
Jun 28, 2007·The Journal of Biological Chemistry·Stephan BöhmKai-Hong Zhao
Mar 25, 2010·Journal of the American Chemical Society·Elizabeth B SawyerPaul D Barker

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