PMID: 8942328Oct 1, 1996Paper

Extradural clonidine combined with sufentanil and 0.0625% bupivacaine for analgesia in labour

British Journal of Anaesthesia
D ChassardP Boulétreau

Abstract

We have studied the use of clonidine combined with low doses of sufentanil and bupivacaine in 45 parturients requiring extradural analgesia for the first stage of labour, in a double-blind, randomized study. We gave 0.0625% bupivacaine 10 ml containing 1:200,000 adrenaline and sufentanil 10 micrograms (1 ml) to which was added 0.9% saline, or clonidine 100 or 150 micrograms (1 ml). We compared the quality (VAS scores) and duration of analgesia, motor block, maternal haemodynamic state (mean arterial pressure and heart rate) and fetal and maternal side effects. Mean duration of anaesthesia was prolonged slightly: 105 (SD 21) min without clonidine, 130 (26) min with clonidine 100 micrograms (P < 0.05 vs control) and 144 (40) min with clonidine 150 micrograms (P < 0.01 vs control, ns vs 100 micrograms). There were no differences in VAS scores, onset times, heart rate, ventilatory frequency, motor block, sedation, pruritus or bradycardia between the groups. Analgesia was associated with a reduction in mean arterial pressure with clonidine. However, these adverse side effects were of minor clinical importance regardless of the extradural clonidine dose, except for a high incidence of fetal heart tracing abnormalities when clonidine ...Continue Reading

Citations

Jun 15, 2007·Advances in Therapy·Nurten KayacanM Erman
Oct 1, 2010·Indian Journal of Anaesthesia·Tanmoy GhatakVinod Kumar Bhatia
Oct 12, 2010·Saudi Journal of Anaesthesia·Sukhminder Jit Singh BajwaJasbir Kaur
Jan 15, 2008·Journal de gynécologie, obstétrique et biologie de la reproduction·L ArnaoutA Mignon
Apr 23, 2004·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Samuel J HassenbuschK Dean Willis
Feb 2, 2010·Revista española de anestesiología y reanimación·M Van de Velde
Mar 6, 2010·International Journal of Obstetric Anesthesia·P Y DewandreJ F Brichant
Sep 26, 2008·Basic & Clinical Pharmacology & Toxicology·Mohammad TariqHaseeb Ahmad Khan
Apr 22, 2006·Annales Françaises D'anesthèsie Et De Rèanimation·E Lopard
Oct 13, 2000·European Journal of Anaesthesiology·S KizilarslanE Sağiroğlu
Aug 29, 2002·Anesthesia and Analgesia·Ruth LandauChristian Kern
Aug 29, 2002·Anesthesia and Analgesia·Chritophe AvelineFrancis Bonnet

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