PMID: 7025875Sep 1, 1981Paper

Extradural morphine for pain after surgery

British Journal of Anaesthesia
W A ChambersD Scott

Abstract

The effects of 10 mg of morphine sulphate given either extradurally or i.m. for the relief of pain after operation were compared in two randomized double-blind trials in patients undergoing major gynaecological surgery. In the first trial when morphine was given with the local anaesthetic before surgery, extradural administration resulted in significantly longer lasting analgesia: mean 707 min compared with 371 min (i.m.). In the second trial in patients complaining of pain after operation, extradural morphine had a slower onset of action, but longer duration of action compared with i.m. morphine, although the differences were not statistically significant. In this group extradural morphine often failed to provide useful analgesia. The extradural group received significantly less additional morphine (6.75 mg) than did the i.m. group (18.75 mg) in the following 24 h.

Citations

Mar 1, 1989·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·R C EtchesM D Daley
Feb 24, 2001·Journal of Chromatography. a·C D Stalikas, C N Konidari
Jan 1, 1993·Journal of Clinical Anesthesia·Y SaitoY Kosaka
Jun 1, 1990·Journal of Pain and Symptom Management·L B Ready
Oct 1, 1982·Acta Anaesthesiologica Scandinavica·L RybroM Wernberg
Jan 1, 1984·Acta Anaesthesiologica Scandinavica. Supplementum·G Nordberg
Jan 1, 1985·Acta Anaesthesiologica Scandinavica·R StensethH Breivik
Feb 27, 2003·Journal of Veterinary Pharmacology and Therapeutics·C PacharinsakP W Kalivas
Jan 1, 1983·The Journal of International Medical Research·Y Adu-GyamfiM Naguib

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