PMID: 7025874Sep 1, 1981Paper

Extradural opioids for postoperative analgesia. A double-blind comparison of pethidine, fentanyl and morphine

British Journal of Anaesthesia
D V RutterM Morgan

Abstract

Pethidine 50 mg, fentanyl 100 microgram and morphine 2 mg administered to the extradural space, were compared in the treatment of pain following surgery. All three drugs produced a rapid decrease in pain scores as assessed using a visual linear analogue, morphine being the least effective. Fentanyl had a relatively short duration of action (2 h), whereas morphine appeared to be the longest acting. It is suggested that the best relief of pain would be obtained by incremental doses given extradurally. All drugs produced an increase in sedation, but there was no respiratory depression as assessed by PaCO2 measurement.

Citations

Mar 1, 1989·Der Schmerz·P Löhmer, W Tolksdorf
Jan 1, 1987·Acta Anaesthesiologica Scandinavica. Supplementum·T L Yaksh
Apr 8, 1999·Anaesthesia·J A Gedney, E H Liu
Mar 1, 1989·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·R C EtchesM D Daley
Oct 1, 1982·Acta Anaesthesiologica Scandinavica·E HjortsøM Lunding
Jul 1, 1985·Anaesthesia·R DonadoniG Vanden Bussche
Jun 10, 1998·Anaesthesia and Intensive Care·W D Ngan Kee
Oct 28, 2011·Regional Anesthesia and Pain Medicine·Sonal SharmaMarcel E Durieux

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