Extraepithelial intraneural endocrine cells as starting-points for gastrointestinal carcinoids

Virchows Archiv. A, Pathological Anatomy and Histopathology
L Auböck, H Höfler

Abstract

Endocrine cells can be demonstrated by light- and electron microscopy in the lamina propria of the mucosa of the appendix. They are always in direct contact with a nerve fibre. The endocrine cell (type EC1 and EC2 cell) and the polyaxonal non-myelinated nerve fibre are separated from the interstitial connective tissue by a common continuous basal lamina. The term "ECC-NF complex" ("EC cell-nerve fibre complex") is suggested by the authors to describe this morphological unit. The intraneural endocrine cells may be derived from neuroendocrine-programmed ectoblasts (Pearse, 1977). The electron microscopic demonstration of these "ECC-NF complexes" in carcinoid tumours of the appendix and of similarly structured "eC-NF complexes" ("endocrine cell-nerve fibre complexes") in carcinoids of the rectum allows us, following the demonstration of small nerve fibres within carcinoids of the appendix, caecum and rectum (and bronchus) to propose a hypothetical pathogenesis of gastrointestinal carcinoid tumours from these intraneural endocrine cells. Carcinoid tumours may develop by proliferation of the intraneural endocrine cells with microcarcinoids as intermediate stages. In this way the histogenesis of the carcinoids is located a priori in ...Continue Reading

References

May 20, 1977·Zeitschrift Für Krebsforschung Und Klinische Onkologie. Cancer Research and Clinical Oncology·B WernerK Dahm
Mar 1, 1976·Cancer·A Churg, M L Warnock
Jan 1, 1976·Progress in Histochemistry and Cytochemistry·S B Doty, B H Schofield
Oct 1, 1975·Journal of the National Cancer Institute·J SogaM Sano
May 1, 1974·Diseases of the Colon and Rectum·F J Hernandez, B B Fernandez
May 1, 1969·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A G Pearse
Jun 1, 1973·Journal of the National Cancer Institute·C CapellaK C Snell
Jan 1, 1981·Virchows Archiv. A, Pathological Anatomy and Histology·M RatzenhoferF Lembeck
Apr 1, 1981·The American Journal of Surgical Pathology·P Isaacson
Jan 1, 1952·Acta Neurovegetativa·F FEYRTER

❮ Previous
Next ❯

Citations

Jan 1, 1987·Journal of Cancer Research and Clinical Oncology·F Shimamoto, E Vollmer
Jan 1, 1986·Archives of Dermatological Research·Y MérotJ H Saurat
Jan 1, 1985·Acta Neuropathologica·E WilanderT Movin
Jan 1, 1984·Virchows Archiv. A, Pathological Anatomy and Histopathology·H Höfler, H Denk
Dec 1, 1992·Digestive Diseases and Sciences·J M ReimundR Baumann
Jul 1, 1992·Diseases of the Colon and Rectum·A P Griffiths, M F Dixon
Mar 1, 1986·Acta Pathologica Japonica·H IshikuraM Aizawa
Jan 1, 1986·Acta Pathologica Japonica·C TorikataK Kageyama
Sep 26, 2012·Pathology International·Shunichi SasouNorihiko Kudara
May 1, 1987·Journal of Clinical Pathology·J RodeJ L O'Riordan
Feb 1, 1989·Pathology, Research and Practice·M LundqvistE Wilander
Apr 1, 1988·Pathology, Research and Practice·G ChejfecV E Gould
Nov 29, 2007·Histopathology·S van EedenM-L F van Velthuysen
Jun 27, 2014·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·A D MalkanJ A Sandoval
Mar 28, 1998·The American Journal of Gastroenterology·A Sandor, I M Modlin
Mar 1, 1995·The British Journal of Surgery·G T Deans, R A Spence
Aug 8, 2008·The American Journal of Surgical Pathology·Laura H TangDavid S Klimstra
Nov 1, 1990·The Journal of Pathology·P A Shaw
Oct 1, 1990·European Journal of Clinical Investigation·E SolciaC Capella
Mar 1, 1989·Journal of Morphology·Y AlbaJ J Vázquez
Feb 1, 1986·Journal of Cutaneous Pathology·Y Merot, J H Saurat
Nov 4, 2010·Archives of Pathology & Laboratory Medicine·Laura H Tang
Dec 1, 1996·Baillière's Clinical Gastroenterology·A E Bishop, J M Polak

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.