Extrafollicular plasmablast B cells play a key role in carrying retroviral infection to peripheral organs

The Journal of Immunology : Official Journal of the American Association of Immunologists
D FinkeH Acha-Orbea

Abstract

B cells can either differentiate in germinal centers or in extrafollicular compartments of secondary lymphoid organs. Here we show the migration properties of B cells after differentiation in murine peripheral lymph node infected with mouse mammary tumor virus. Naive B cells become activated, infected, and carry integrated retroviral DNA sequences. After production of a retroviral superantigen, the infected B cells receive cognate T cell help and differentiate along the two main differentiation pathways analogous to classical Ag responses. The extrafollicular differentiation peaks on day 6 of mouse mammary tumor virus infection, and the follicular one becomes detectable after day 10. B cells participating in this immune response carry a retroviral DNA marker that can be detected by using semiquantitative PCR. We determined the migration patterns of B cells having taken part in the T cell-B cell interaction from the draining lymph node to different tissues. Waves of immigration and retention of infected cells in secondary lymphoid organs, mammary gland, salivary gland, skin, lung, and liver were observed correlating with the two peaks of B cell differentiation in the draining lymph node. Other organs revealed immigration of infe...Continue Reading

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Citations

Dec 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Erin S BromageStephen L Kaattari
Jul 9, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rachael RacineGary M Winslow
Apr 17, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Simon W F MokNeil A Mabbott
Dec 28, 2002·Proceedings of the National Academy of Sciences of the United States of America·Daniela FinkeHans Acha-Orbea
Jul 9, 2003·Immunological Reviews·Jason G Cyster
Jul 29, 2005·Immunological Reviews·Marko Salmi, Sirpa Jalkanen
Jul 1, 2014·Nature Communications·Yan-Feng LiKong-Peng Lam
Nov 3, 2014·Annual Review of Virology·Theodore C Pierson, Michael S Diamond
Mar 16, 2019·Immunological Reviews·Scott A JenksIgnacio Sanz
Oct 3, 2003·Nature Reviews. Immunology·Eric J Kunkel, Eugene C Butcher
Dec 14, 2011·Nature Reviews. Immunology·Harald RenzMathias Hornef
Sep 21, 2013·Veterinary Pathology·B VidañaJ Martínez

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