PMID: 9537212Apr 16, 1998Paper

Extragonadal germ-cell tumors: a ten-year experience

American Journal of Clinical Oncology
R JacobM K Nair

Abstract

Extragonadal germ-cell tumors (EGCT) are uncommon and biologically distinct from their gonadal counterparts. Thirty-seven patients who had EGCT were treated over a ten-year period at the Regional Cancer Centre, Trivandrum, India. There were 26 men and boys and 11 women and girls. The sites of primary tumor were mediastinum (n=18), central nervous system (n=5), sacrococcygeal region (n=4), retroperitoneum (n=2), and other sites (n=8). After combined modality therapy, 13 of 18 patients who had mediastinal EGCT--1 of 2 with retroperitoneal, 1 of 4 with sacrococcygeal, 0 of 5 with central nervous system, and 2 of 8 patients with tumor in other sites-were alive with no evidence of disease at a median follow-up of 16 months. The overall 5-year survival rate was 40%. Histologic subtype and elevated marker levels were the significant prognostic factors on univariate analysis.

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Aug 15, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R Amato
Nov 19, 1988·BMJ : British Medical Journal·G M Mead
Dec 10, 2003·Cancer Science·Hiromichi EbiHironobu Minami

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