PMID: 11933147Apr 5, 2002Paper

Extrahepatic biliary obstruction: can silymarin protect liver function?

Phytotherapy Research : PTR
Krisztina HagymásiA Blázovics

Abstract

The hepatoprotective property of silymarin is well known. However, it is not known whether the antioxidant silymarin might have a beneficial effect in extrahepatic cholestasis in common bile duct ligated rats. Malonaldehyde property concentrations, the hydrogen-donating ability and reducing power were measured in liver homogenates by spectrophotometry, as well as free SH-group levels and glutathione-reductase activities in sera. The total scavenger capacity of the livers was quantified by a chemiluminometric method. The elevated lipid peroxidation and decreased antioxidant capacity of liver homogenates and sera could be observed in ligated rats. Silymarin pretreatment improved the antioxidant capacity of the liver, diminished the direct bilirubin concentration and caused an increase of liver enzyme activities compared with the groups without treatment. These effects of silymarin suggest that it may be a useful agent for improving the antioxidant defensive system in extrahepatic cholestasis, but its choleretic property should be considered.

References

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Jun 1, 1996·Journal of Korean Medical Science·K C MunK Y Kwon

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Citations

Aug 10, 2006·Pediatric Surgery International·Abdurrahman KaramanErsin Fadillioglu
Jun 5, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Changxing JiangQingping Xiong
Oct 10, 2012·Carbohydrate Polymers·Changxing JiangXiaoxiong Zeng
Feb 11, 2014·Carbohydrate Polymers·Predeep Kumar Samal, Jawahar Singh Dangi
Jan 11, 2017·Toxicology and Industrial Health·Seyedeh Missagh JalaliSadegh Bahmei
Apr 29, 2016·Canadian Journal of Physiology and Pharmacology·Mohamed Elsayed Kelany, Mohamed Abdelmohsen Abdallah

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