PMID: 3772743Aug 1, 1986Paper

Extrahepatic metabolism and distribution of aspirin in vascular beds of sheep

Journal of Pharmaceutical Sciences
P A CossumA C Yong

Abstract

The dispositions of aspirin, its metabolite, salicylic acid, and its subsequent metabolite, salicyluric acid, were studied in eight anesthetized sheep infused with aspirin (61 and 485 microgram X min-1 X kg-1) for 75 min. Plasma samples were withdrawn from the portal vein, hepatic vein, pulmonary artery, left ventricle, left femoral vein, and left femoral artery. Significant extraction of aspirin occurred across the liver and hind leg, with mean availabilities of 0.75, 0.98, and 0.82 observed across the liver, lung, and hind leg, respectively. The extraction of aspirin was not affected by coadministration of sodium salicylate (30-1200 mg equiv salicylic acid). This extraction reflected hydrolysis of aspirin to salicylic acid; the metabolism of aspirin in the hind leg, lung, and liver being confirmed with tissue homogenate studies. The metabolism of aspirin in the extrahepatic tissues is significant in relation to the proposed selective presystemic acetylation of platelet cyclooxygenase by aspirin and the use of low-dose aspirin for thrombotic indications.

References

May 1, 1977·Stroke; a Journal of Cerebral Circulation·W S FieldsR J Hardy
Mar 1, 1972·Journal of Pharmaceutical Sciences·M RowlandS D Sholkoff
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Citations

Nov 26, 2010·Journal of Pharmacokinetics and Pharmacodynamics·Michael S Roberts
Jan 1, 1990·Pharmacology & Therapeutics·K F IlettR F Minchin
Jan 9, 2013·Expert Opinion on Drug Metabolism & Toxicology·Xin LiuMichael S Roberts
Jan 1, 1991·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·R N UptonW B Runciman
Dec 1, 1990·Biopharmaceutics & Drug Disposition·R N UptonL E Mather

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