PMID: 6980401Mar 1, 1982Paper

Extrahypothalamic distribution of CRF-like immunoreactivity in the rat brain

Peptides
A J Fischman, R L Moldow

Abstract

CRF-like immunoreactivity was measured by radioimmunoassay in the brains of normal adult rats and found to be widely distributed in extrahypothalamic areas (e.g., thalamus, amygdala, hippocampus, frontal cerebral cortex, striatum, midbrain, pons-medulla and cerebellum) at levels approximately 10% of the hypothalamus. Sephadex G-50 gel filtration reveals that CRF-like immunoreactivity in the hypothalamus coelutes with synthetic ovine CRF and is also present in the void volume. However, in the extrahypothalamic areas of the rat brain, only CRF-like immunoreactivity that coelutes with synthetic ovine CRF was detected. High performance liquid chromatography revealed equal amounts of immunoreactivity coeluting with CRF and methionine sulfoxide CRF in hypothalamic extracts.

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Jan 1, 1982·Peptides·R L Moldow, A J Fischman

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Citations

Sep 1, 1982·Peptides·A J Fischman, R L Moldow
Mar 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·P PetruszA V Schally
May 28, 1993·Annals of the New York Academy of Sciences·G MastorakosG P Chrousos
Jun 17, 1997·Annals of the New York Academy of Sciences·G MastorakosG P Chrousos
Jun 17, 1997·Annals of the New York Academy of Sciences·A MakrigiannakisA Gravanis
Aug 1, 1993·The Journal of Clinical Investigation·G MastorakosG P Chrousos
Aug 2, 2006·Reviews in the Neurosciences·Luis Orozco-CabalJoel P Gallagher
Dec 3, 2011·International Journal of Medical Sciences·Tasneem Fatema Hasan, Hunaid Hasan
Mar 18, 2008·European Journal of Pharmacology·Joel P GallagherPatricia Shinnick-Gallagher
Jun 18, 2004·General and Comparative Endocrinology·Graham C Boorse, Robert J Denver
Jan 1, 1992·Neuroscience and Biobehavioral Reviews·P RosenfeldS Levine
Feb 15, 1989·The Journal of Comparative Neurology·D E Williamson, W D Eldred
Apr 15, 1988·The Journal of Comparative Neurology·M SakanakaK Lederis

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