Extraintestinal Manifestations in Patients with Inflammatory Bowel Disease: Study Based on the ENEIDA Registry.

Digestive Diseases and Sciences
Alicia AlgabaSpanish GETECCU Group (ENEIDA Project)

Abstract

Patients with inflammatory bowel disease (IBD) may present extraintestinal manifestations (EIMs) that affect the joints, skin, eyes, and hepatobiliary area, among others. Our aim was to analyse the prevalence and characteristics of EIMs in patients with IBD and to identify the possible risk factors associated with the development of EIMs in the largest series published to date. Observational, cross-sectional study including patients from the Spanish ENEIDA registry promoted by GETECCU. We retrospectively identified all cases of EIMs in the ENEIDA registry until January 2018. The study included 31,077 patients, 5779 of whom had at least one EIM (global prevalence 19%; 95% CI 18.2-19.0). Among the different types of EIMs, rheumatic manifestations had a prevalence of 13% (95% CI 12.9-13.7; 63% of EIMs), with a prevalence of 5% (95% CI 4.7-5.2) for mucocutaneous manifestations, 2.1% (95% CI 1.9-2.2) for ocular manifestations, and 0.7% (95% CI 0.6-0.8) for hepatobiliary manifestations. The multivariable analysis showed that the type of IBD (Crohn's disease, p < 0.001), gender (female, p < 0.001), the need for an immunomodulator (p < 0.001) or biologic drugs (p < 0.001), a previous family history of IBD (p < 0.001), and an extensive ...Continue Reading

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Citations

Nov 4, 2020·International Journal of Environmental Research and Public Health·Koen M J JanssenJohanna Westra
Nov 24, 2020·Gastroenterología y hepatología·Paulina NuñezFernando Gomollón
Aug 26, 2021·United European Gastroenterology Journal·René RothUNKNOWN Swiss IBD cohort study
Aug 26, 2021·United European Gastroenterology Journal·Iago Rodríguez-Lago, Manuel Barreiro-de Acosta
Sep 28, 2021·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Krishn Kant RawalRajesh K Chudasama

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