Extraintestinal Pathogenic Escherichia coli, a Common Human Pathogen: Challenges for Vaccine Development and Progress in the Field

The Journal of Infectious Diseases
Jan T Poolman, Michael Wacker

Abstract

Extraintestinal pathogenic Escherichia coli (ExPEC) is the most common gram-negative bacterial pathogen in humans. ExPEC causes the vast majority of urinary tract infections (UTIs), is a leading cause of adult bacteremia, and is the second most common cause of neonatal meningitis. Increasing multidrug resistance among ExPEC strains constitutes a major obstacle to treatment and is implicated in increasing numbers of hospitalizations and deaths and increasing healthcare costs associated with ExPEC infections. An effective vaccine against ExPEC infection is urgently needed. The O antigen, a component of the surface lipopolysaccharide, has been identified as a promising vaccine target. With the availability of a novel bioconjugation technology it is expected that multivalent O antigen conjugate vaccines can be produced at industrial scale. Clinical proof of concept of a 4-valent O antigen conjugate vaccine is ongoing. An ExPEC vaccine effective against strains that are associated with major diseases and resistant to multiple drugs could be routinely delivered to individuals at risk of developing severe E. coli infection, such as elderly people, individuals undergoing abdominal surgery and prostatic biopsy procedures, and persons at...Continue Reading

References

Aug 1, 1977·Infection and Immunity·B Kaijser, S Ahlstedt
Jul 1, 1992·Canadian Journal of Microbiology·F Orskov, I Orskov
Sep 15, 1990·FEMS Microbiology Letters·J J MeulenbergP W Postma
Dec 1, 1985·The Journal of Hygiene·I Orskov, F Orskov
Feb 1, 1984·The Journal of Infectious Diseases·A S CrossI Orskov
Mar 15, 1984·The New England Journal of Medicine·T SöderströmG Larson
Oct 1, 1994·The Journal of Infectious Diseases·A CrossS J Cryz
Dec 10, 1998·Journal of Internal Medicine·L LeiboviciS D Pitlik
Jul 20, 2002·Biologicals : Journal of the International Association of Biological Standardization·Chi Jen Lee
Feb 11, 2005·Proceedings of the National Academy of Sciences of the United States of America·Mario F FeldmanMarkus Aebi
Apr 6, 2005·The Journal of Infectious Diseases·Lisa A JacksonJennifer L Marino
Apr 16, 2005·Science·Paul B EckburgDavid A Relman
Apr 6, 2006·FEMS Microbiology Reviews·Roland StenutzGöran Widmalm
Jun 8, 2006·Annual Review of Biochemistry·Chris Whitfield
Jun 25, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·James R JohnsonMariana Castanheira
Jul 6, 2010·Vaccine·Ron DaganClaire-Anne Siegrist
Aug 13, 2010·Microbial Cell Factories·Julian IhssenLinda Thöny-Meyer
Dec 15, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mette SøgaardHenrik Carl Schønheyder
Mar 23, 2012·The Journal of Antimicrobial Chemotherapy·Iryna SchlackowUNKNOWN Infections in Oxfordshire Research Database Team
Oct 9, 2012·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M E A de KrakerH Grundmann
Dec 12, 2012·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Dawn M SievertUNKNOWN National Healthcare Safety Network (NHSN) Team and Participating NHSN Facilities
Mar 28, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Deborah A WilliamsonDavid L Paterson
Aug 7, 2013·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Marya D Zilberberg, Andrew F Shorr
Dec 5, 2013·Microbiology and Immunology·Lutz GeueRalf Ehricht
Dec 24, 2013·Diagnostic Microbiology and Infectious Disease·John EdelsbergDavid J Weber
Feb 4, 2014·Infectious Disease Clinics of North America·Betsy Foxman
Mar 13, 2014·FEMS Microbiology Letters·Helen Miajlovic, Stephen G Smith
Jun 19, 2014·Canadian Urological Association Journal = Journal De L'Association Des Urologues Du Canada·Jan Krzysztof Rudzinski, Jun Kawakami
Oct 4, 2014·Clinical Microbiology Reviews·Kevin B Laupland, Deirdre L Church
Dec 18, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael A LissJoshua Fierer
Jan 18, 2015·Advances in Applied Microbiology·Amy J MathersJohann D D Pitout
Mar 19, 2015·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Ina WillemsenJan Kluytmans

❮ Previous
Next ❯

Citations

Apr 12, 2016·Frontiers in Microbiology·Priyanka BajajJugsharan S Virdi
Jun 9, 2016·International Journal of Experimental Pathology·Karellen Beren García MéndezAnne Keriel
Jun 23, 2016·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·H CiesielczukD W Wareham
Aug 3, 2016·Microbes and Infection·Alexis GarcíaJames G Fox
May 23, 2018·Human Vaccines & Immunotherapeutics·Kathrin U Jansen, Annaliesa S Anderson
Jun 12, 2018·PloS One·Anouk M Oordt-SpeetsMoe H Kyaw
Jan 10, 2018·Nature Medicine·Kathrin U JansenAnnaliesa S Anderson
Jan 8, 2018·Microbial Genomics·Cameron J ReidSteven P Djordjevic
Oct 4, 2017·Clinical and Vaccine Immunology : CVI·Darren AbbanatGermie P J M van den Dobbelsteen
May 15, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Marc BontenJan T Poolman
Jan 5, 2020·Journal of Biomedical Science·Wen-Chun HuangChing-Hao Teng
Jul 31, 2020·Microbiology and Molecular Biology Reviews : MMBR·Mario ZamoraAlan J Wolfe
May 10, 2020·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Alireza JafariHadi Sedigh Ebrahim-Saraie

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.