Extraluminal cooling of bilateral common carotid arteries as a method to achieve selective brain cooling for neuroprotection

Journal of Neurotrauma
Guo WeiXi-Chun M Lu

Abstract

Systemic cooling to achieve brain hypothermia has been investigated as a neuroprotective therapy but can present serious adverse effects. Here we describe a novel method to selectively cool the rat brain and investigate its neuroprotective effects following transient middle cerebral artery occlusion (MCAo). The novelty of our method of selective brain cooling (SBC) was that the extraluminal cooling of the carotid arterial blood was achieved by using a cooling cuff wrapped around each common carotid artery (CCA). Within 20 min of CCA cooling, brain temperature could be lowered by 2-5 degrees C below the baseline and maintained stable for approximately 2 h while maintaining body temperature at 37 degrees C. No adverse effects of SBC were observed on systemic physiology, regional cerebral blood flow (rCBF), bleeding time, or tissue histology in normal animals. In rats having sustained 2-h MCAo, intra-ischemic SBC for 90 min, initiated 30 min following the onset of ischemia, significantly reduced infarction measured at 24 h post-injury (normothermic rats=312+/-51 mm3, SBC rats=139+/-83 mm3). In subgroup experiments, the incidence of peri-infarct depolarization (PID) was assessed during the MCAo and cooling period. Compared to normo...Continue Reading

References

Jan 1, 1994·Acta Neuropathologica·J TowfighiJ Y Yager
May 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Q ChenH Chen
Nov 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·E BuschK A Hossmann
Jan 1, 1997·Neuroscience and Biobehavioral Reviews·F C BaroneR F White
Apr 1, 1997·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·I Kronzon
Feb 5, 2000·Stroke; a Journal of Cerebral Circulation·Y WangJ Fisher
Feb 5, 2000·Stroke; a Journal of Cerebral Circulation·C HajatP Sharma
Mar 21, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K ChatzipanteliW D Dietrich
Feb 24, 2001·The New England Journal of Medicine·G L CliftonM Schwartz
Apr 3, 2001·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·K MoriE W Dickson
Nov 3, 2001·Stroke; a Journal of Cerebral Circulation·D GeorgiadisS Schwab
Feb 9, 2002·The Annals of Thoracic Surgery·Marek P EhrlichRandall B Griepp
May 9, 2002·Neuroreport·Anthony J WilliamsFrank C Tortella
Aug 14, 2003·Intensive Care Medicine·William R HendersonJuan J Ronco
Apr 17, 2004·Journal of Neurosurgery·Huan WangDavid Wang
Jun 9, 2004·Intensive Care Medicine·Hubert TrübelFahmeed Hyder
Mar 12, 2005·The Journal of Trauma·Yi-Szu WenChen-Hsen Lee
Apr 1, 2005·The New England Journal of Medicine·Ralph G DePalmaMichael J Hodgson
May 28, 2005·The Journal of Trauma·Wenjun Z MartiniJohn B Holcomb
Sep 24, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jed A HartingsMichael L Rolli
Feb 21, 2006·Acta neurochirurgica·H ChengL Wang
May 4, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Darren L Clark, Frederick Colbourne
Jul 18, 2006·Neurobiology of Disease·F C SchmittM Holtkamp
Sep 20, 2006·The Journal of Head Trauma Rehabilitation·Deborah Warden
Nov 14, 2006·Acta Anaesthesiologica Scandinavica·B RomlinK Nilsson
Jan 31, 2007·Stroke; a Journal of Cerebral Circulation·Thomas M Hemmen, Patrick D Lyden
Apr 12, 2007·World Journal of Surgery·Brandon H TieuMartin A Schreiber
Apr 12, 2007·Neurological Research·Motomasa FuruseToshihiko Kuroiwa
Apr 13, 2007·European Journal of Applied Physiology·Yunjian Wang, Liang Zhu

❮ Previous
Next ❯

Citations

Feb 17, 2009·Journal of Neurotrauma·Crystal L MacLellanFrederick Colbourne
Jan 1, 2011·Therapeutic Hypothermia and Temperature Management·Guo WeiFrank C Tortella
Apr 30, 2009·Annual Review of Biomedical Engineering·Kenneth R Diller, Liang Zhu
Oct 3, 2008·Neurosurgical Focus·Eisha ChristianSteven L Giannotta
Dec 4, 2014·Journal of the Chinese Medical Association : JCMA·Ya-Pei ChangI-Hsuan Liu
Jul 30, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Xi-Chun M LuFrank C Tortella
May 24, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Christy JosephAurel Popa-Wagner
Oct 8, 2015·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Erik Sveberg Dietrichs, Espen Dietrichs
Jun 22, 2016·Therapeutic Hypothermia and Temperature Management·Ana C KlahrFrederick Colbourne
Feb 3, 2012·Arquivos de neuro-psiquiatria·David StrausLorenzo Munoz
Dec 30, 2017·International Journal of Molecular Sciences·Raluca Elena SanduEugen Bogdan Petcu
Jan 18, 2020·Brain Circulation·Fabrizio R AssisHarikrishna Tandri
Jul 15, 2020·Mechanisms of Ageing and Development·Aurel Popa-WagnerAndrei Gresita

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carotid Artery Diseases

Carotid artery disease is a group of pathological conditions of the carotid artery. Discover the latest research on carotid artery disease here.

© 2022 Meta ULC. All rights reserved