PMID: 8600776Apr 1, 1995Paper

Extramedullary hematopoiesis in pilomatricomas

The American Journal of Dermatopathology
S KadduH Kerl

Abstract

We report on seven adult patients with pilomatricomas showing histopathologic findings of extramedullary hematopoiesis. There was no Ovidence of hematological disorders or systemic diseases. Clinically, the lesions appeared to be firm, painless nodules situated on the upper extremities, head, and back. Histopathologically, they represented stereotypical examples of regressive pilomatricomas with relatively small basaloid areas and large masses of cornified eosinophilic material containing shadow cells with variable areas of calcification or ossification. Bone marrow cellular elements, including myeloid and erythroid precursors, and (in two cases) megakaryocytes were present. The finding of extramedullary hematopoiesis in seven (5.8%) of 120 cases of pilomatricomas may suggest that this phenomenon is not uncommon in these neoplasms. Interestingly, hematopoietic infiltrates were histopathologically detected to be contiguous with areas of osseous metaplasia in only two of the seven pilomatricomas in our study. It should further be stressed that extramedullary hematopoiesis in regressive lesions of pilomatricomas is a localized phenomenon and that these findings may not be linked with a systemic hematological disorder. The signific...Continue Reading

Citations

Mar 6, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Dennis P O'Malley
Feb 13, 2001·International Journal of Dermatology·F RevengaJ Paricio
Apr 1, 1996·The American Journal of Dermatopathology·S Falk
Jun 1, 1997·The American Journal of Dermatopathology·S Farrier, M Morgan
Oct 26, 2000·The American Journal of Dermatopathology·C G RowlandsT Morell
Apr 18, 2001·The Journal of Clinical Investigation·M P MaciasN A Lee
Oct 20, 1998·Journal of the American Academy of Dermatology·D M Touart, P Sau
Jun 23, 2015·Journal of Cutaneous Pathology·Justin D Richey, Jeffrey P North
Jul 27, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·D A Hill, P E Swanson
Jul 23, 2004·Journal of Cutaneous Pathology·Suzana M Vega HarringMotoshige Kudo
May 17, 2019·Journal of Cutaneous Pathology·Graziana GalloAnna Maria Cesinaro
Jul 28, 2019·Experimental Dermatology·Shadi KhalilArturo P Saavedra
Mar 30, 2013·The American Journal of Dermatopathology·Chiara BaldoviniGianluca Marucci
Aug 1, 1996·The American Journal of Dermatopathology·S KadduH Kerl
Aug 23, 2019·The American Journal of Dermatopathology·Nathan M JohnsonDouglas J Grider

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The American Journal of Dermatopathology
T H McCalmont
The American Journal of Dermatopathology
N Misago, Y Narisawa
The Journal of Dermatologic Surgery and Oncology
P J WeberH C Rabinovitz
© 2021 Meta ULC. All rights reserved