Extraneural spread of glioblastoma--report of two cases

Onkologie
Arnoud TempletonSilke Gillessen

Abstract

Glioblastoma, a highly aggressive tumor, accounts for the majority of all primary brain tumors in adults. Despite a destructive local growth pattern, extraneural spread of these tumors is extremely rare. CASE 1: We describe the case of a 58-year-old man with glioblastoma, in whom an epidural mass was diagnosed 5 months after initial local therapy of the brain. A positron emission tomography (PET) scan revealed multiple metastases in the lungs, in the retroperitoneum, and in the left trochanter minor region. A soft tissue swelling of the right thigh was histologically proven to be metastatic tissue from the primary glioblastoma. The patient died 11 months after initial diagnosis. CASE 2: A 47-year-old woman with recurrent glioblastoma had a long lasting complete response to chemotherapy. 2 years after initial diagnosis she presented with a pleural mass which was a metastasis of the formerly diagnosed glioblastoma. Although systemic metastases in glioblastoma are rare, different organs can be involved.

References

Nov 1, 1989·Journal of Neurosurgery·D LeiferE T Hedley-Whyte
Oct 1, 1985·Cancer·H J Hoffman, P K Duffner
Jan 17, 1995·International Journal of Cancer. Journal International Du Cancer·S A BirkelandL Frödin
Jan 1, 1996·Transplant International : Official Journal of the European Society for Organ Transplantation·S JonasP Neuhaus
Oct 20, 1999·Acta neurochirurgica·A PieralliniL Bozzao
Oct 6, 2000·International Journal of Radiation Oncology, Biology, Physics·S C HoustonJ J Olson
Jan 4, 2001·Journal of Neuropathology and Experimental Neurology·C C ParkD N Louis
Jan 25, 2002·Journal of the American Academy of Dermatology·Patricio FigueroaVirginia I Sulica
Jul 31, 2002·The Lancet Oncology·A SubramanianR Bradford
Mar 11, 2005·The New England Journal of Medicine·Roger StuppUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Jun 1, 2005·Journal of Neuro-oncology·Vandana RajagopalanMichael L Grossbard
Oct 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James J VredenburghHenry S Friedman

❮ Previous
Next ❯

Citations

Feb 26, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jackson D HamiltonChristiane Matuschek
Jan 22, 2020·BMC Cancer·Melissa UmphlettRaymund L Yong
Jun 1, 2021·Neuro-oncology Practice·Evan K NochAlexandra M Miller
Aug 1, 2009·Archives of Pathology & Laboratory Medicine·Peter Pytel, Rimas V Lukas

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.