Extranodal mantle cell lymphoma mimicking marginal zone cell lymphoma

Histopathology
I AnagnostopoulosH Stein

Abstract

We report a case of mantle cell lymphoma masquerading as a marginal zone cell lymphoma. In the initial manifestation in the palatine tonsils, the neoplastic cells were found to grow exclusively within the marginal zones of secondary follicles which showed a preserved mantle zone. The few immunostains performed showed a B-cell phenotype including an immunoglobulin light chain restriction. The extranodal manifestation, the growth pattern, and the immunophenotype led to the diagnosis of an extranodal marginal zone B-cell non-Hodgkin's lymphoma (NHL). The specimen from the relapse occurring 8 months later exhibited diffuse monomorphous cells co-expressing B-cell antigens and CD5, CD43 and cyclin D1, leading to the diagnosis of mantle cell lymphoma. Re-investigation of the initial biopsy revealed that the neoplastic cells within the marginal zones had a mantle cell lymphoma immunophenotype expressing cyclin D1, the immunoglobulin heavy chains IgD and IgM and partly CD5. Both lesions harboured identical clonal immunoglobulin gene rearrangements proving that they represented different manifestations of the same lymphoma. This case emphasizes the importance of broad immunohistological investigation of B-cell NHLs involving the marginal...Continue Reading

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Citations

Mar 1, 2011·Journal of Hematopathology·Ulla RandenJan Delabie
Aug 29, 2006·Journal of Clinical Pathology·P RichardP Brousset
Jul 19, 2006·Virchows Archiv : an International Journal of Pathology·Ioannis KostopoulosLorenzo Leoncini
Dec 28, 2012·Journal of Clinical and Experimental Hematopathology : JCEH·Yoshinori HashimotoShu Nakamoto
Mar 3, 2011·World Journal of Gastrointestinal Oncology·Xavier SagaertThomas Tousseyn
Jun 25, 2005·Archives of Pathology & Laboratory Medicine·Erica JacobsonBarbara H Tindle
Mar 6, 2008·Archives of Pathology & Laboratory Medicine·Russell A HigginsMarsha C Kinney

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