Abstract
Extranodal marginal zone lymphoma (EMZL) of mucosa-associated lymphoid tissue (MALT) of the uterus is rare, and the etiology, pathophysiology and cytogenetic features remain unknown at present. The present study reports a case of a 71-year-old female with EMZL of the uterine cervix that was 80 mm in diameter and invaded directly into the rectal serosa. Complete remission was successfully induced by 6 courses of immunochemotherapy with rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisolone. Although the metaphase spread of the tumor cells was unavailable for whole cytogenetic analysis, fluorescence in situ hybridization (FISH) detected triple signals for MALT1 and B-cell lymphoma 2, located at chromosome 18q21, and the centromere of chromosome 18, which was suggestive of trisomy 18, and in combination with previous studies, suggested a possible association between trisomy 18 and the large tumor at initial presentation in the present patient. In addition, FISH examination detected immunoglobulin heavy chain gene rearrangement, although the translocation partner was unconfirmed. A total of 18 previously-studied patients with EMZL of the uterus, including that of the present study, were reviewed with respect to ...Continue Reading
References
Nov 1, 1989·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·T A ListerM Tubiana
Nov 1, 1965·Journal of Clinical Pathology·H Fox, J R More
Jun 1, 1984·Cancer·N L Harris, R E Scully
Mar 21, 1998·The American Journal of Surgical Pathology·E BallesterosA Y Matsushima
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P L ZinzaniS Tura
Feb 5, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·R VangM Deavers
May 2, 2002·Gastroenterology·Hongxiang LiuMing-Qing Du
Oct 31, 2002·Blood·Berthold StreubelAndreas Chott
Aug 22, 2003·Leukemia·E M Murga PenasJ Dierlamm
Mar 26, 2004·Cancer Genetics and Cytogenetics·Yosuke MatsumotoMasafumi Taniwaki
Mar 30, 2004·Gynecologic Oncology·Pratibha Iyengar, Sanjeev Deodhare
Sep 10, 2004·Leukemia·B StreubelA Chott
Feb 8, 2005·Best Practice & Research. Clinical Haematology·Peter G Isaacson
Oct 15, 2005·The American Journal of Surgical Pathology·Farid KosariHans-Heinrich Wacker
Oct 13, 2006·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Masaru KojimaNobuhide Masawa
Oct 27, 2006·Leukemia & Lymphoma·Noelle V FreySunita D Nasta
May 26, 2007·Gut·Shotaro NakamuraMing-Qing Du
Jan 19, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Devin CoonRohit Bhargava
Mar 5, 2008·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Joanna H M HeerenJohanna M A Pijnenborg
Oct 14, 2008·Annals of Hematology·O AnnibaliG Avvisati
Jan 9, 2009·Acta Haematologica·Junya KurodaMasafumi Taniwaki
Feb 1, 2012·Leukemia & Lymphoma·Tanwen M WrightMark E F Smith
Oct 31, 2012·American Journal of Obstetrics and Gynecology·Ceana H NezhatMauricio Zapata
Jul 3, 2013·Critical Reviews in Oncology/hematology·Chiara Di TucciPierluigi Benedetti Panici
Dec 20, 2013·Journal of Clinical Pathology·Anita J MerrittRichard J Byers
May 8, 2015·BMC Ophthalmology·Xinxiao GaoXiaoyan Peng