Extranodal natural killer/T cell lymphoma, nasal type in the middle cranial fossa: A case report

Medicine
Han WangCong Qian

Abstract

Extranodal natural killer (NK)/T cell lymphomas, nasal type, are aggressive, non-Hodgkin lymphomas. Extranodal NK/T cell lymphomas, nasal type, involving the central nervous system (CNS) are rare; therefore, delayed diagnosis easily occurs and is associated with a poor prognosis. Early diagnosis and patented systemic chemotherapy are necessary. We present a case of 34-year-old male with facial numbness and diplopia. He was diagnosed with extranodal NK/T cell lymphoma, nasal type, involving the CNS. The tumor, located in the right middle fossa, was subtotally removed, and 3 cycles of systemic chemotherapy were given. He later died of severe neutropenia and infection. NK/T cell lymphomas should be considered to be a potential cause of facial numbness and diplopia. A L-asparaginase-based regimen resulted in reasonable tumor suppression, but adverse effects, including fatal neutropenia, should be carefully considered.

References

Dec 29, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeeyun LeeWon Seog Kim
Jul 17, 2009·British Journal of Haematology·Raymond Liang
May 9, 2013·Blood·Eric Tse, Yok-Lam Kwong
Sep 11, 2014·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Xianping JiangFeiqiu Wen
Feb 11, 2015·Clinical Lymphoma, Myeloma & Leukemia·Ranjit Kumar ChaudharyJulie M Vose
Apr 18, 2017·Molecular and Clinical Oncology·Hong-Cheng MaiYu-Sheng Zhang

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