Extraocular Sebaceous Carcinoma Treated With Mohs Micrographic Surgery-A 24-Year Retrospective Review of Tumor Characteristics and Treatment Outcomes.

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]
Meghan SeagoBenjamin Kelley

Abstract

Extraocular sebaceous carcinoma (SC) is rare, with distinct features from its ocular counterpart. These neoplasms have been associated with Muir-Torre syndrome (MTS). Associated internal malignancies include gastrointestinal and genitourinary. Assess for local recurrence, metastasis, disease-specific death, and additional malignancies in patients with extraocular SC treated with Mohs micrographic surgery (MMS) at a single referral center. Review of patients with extraocular SC treated with MMS between 1995 and 2019. Follow-up was obtained by chart review. Thirty-eight patients with 41 tumors were identified (25, 66% male). During a mean follow-up of 5.9 ± 5 years, one case of metastasis was identified in an incompletely treated case. No recurrence was identified in the remaining 40 tumors. Five of 41 (12%) tumors had aggressive histologic features. Seven of 38 (18%) patients had a diagnosis of MTS or associated risk factors. There was no association between MTS or its risk factors and high-risk tumors. There were no incidences of local recurrence, metastasis, or disease-specific death in cases treated completely with MMS. Metastasis and disease-specific death occurred in an incompletely treated case, highlighting the risk assoc...Continue Reading

References

May 1, 1981·The Journal of Dermatologic Surgery and Oncology·J R MelletteT M Chesney
Aug 1, 1994·The Journal of Dermatologic Surgery and Oncology·A B YountH T Greenway
May 23, 2001·Journal of the American Academy of Dermatology·J M SpencerM Sequeira
Jan 22, 2002·The American Journal of Dermatopathology·C MorenoL Requena
Mar 8, 2005·Survey of Ophthalmology·Jerry A ShieldsCarol L Shields
Nov 7, 2008·Cancer·Tina DasguptaJames B Yu
May 6, 2009·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Adam R SawyerMiklos Pohl
Jul 21, 2009·Journal of Cutaneous Pathology·Doina IvanAlexander J F Lazar
Dec 6, 2012·Journal of Genetic Counseling·Maegan E RobertsMark A Cappel
Jan 28, 2014·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Jennifer L HouJerry D Brewer
Jan 6, 2016·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Aileen Y ChangJoseph F Sobanko
Oct 11, 2016·Journal of the American Academy of Dermatology·Raghav TripathiJeremy S Bordeaux
Feb 7, 2017·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Kimberly L Brady, Eva A Hurst
Jan 15, 2019·Journal of the American Academy of Dermatology·Chuandi ZhouXianqun Fan
Sep 1, 2019·Archives of Dermatological Research·Nour KibbiMurad Alam
Jul 10, 2020·Dermatologic Therapy·Marcus L EliasRobert A Schwartz

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