Extraordinary sensitivity enhancement by metasurfaces in terahertz detection of antibiotics

Scientific Reports
Lijuan XieJunichiro Kono

Abstract

We have detected trace amounts of molecules of antibiotics (kanamycin sulfate) dispersed on metasurfaces with terahertz (THz) spectroscopy. Utilizing the extraordinary optical transmission resonance of an array of square-shaped slits on a silicon substrate at ~0.3 THz, we were able to monitor varying concentrations of kanamycin sulfate as low as ~100 picogram/L. In contrast, the lowest detectable concentration of kanamycin sulfate on silicon without any metallic structure was ~1 gram/L. This dramatic ~10(10) times enhancement of sensitivity is due to the near-field enhancement of THz electric fields by the metamaterial structure. This result thus demonstrates the power and usefulness of metamaterial-assisted THz spectroscopy in trace molecular detection for biological and chemical sensing as well as for food product quality and safety inspection and control.

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Citations

May 2, 2016·Applied Microbiology and Biotechnology·Xiang YangWeiling Fu
Jun 1, 2016·Nano Letters·Mathieu GonidecGeorge M Whitesides
Oct 11, 2016·Food Chemistry·Wendao XuYibin Ying
Apr 4, 2017·Scientific Reports·Om Krishna SuwalDai-Sik Kim
Jan 19, 2019·Sensors·Luigi La Spada
Mar 16, 2018·Biomedical Optics Express·Xiaohui HanChunlei Du
Sep 15, 2020·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Zhang YaxinYang Ziqiang
Aug 6, 2017·Scientific Reports·Maidul IslamDibakar Roy Chowdhury
Jun 7, 2019·Sensors·Gian Paolo PapariAntonello Andreone
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Aug 19, 2020·ACS Applied Materials & Interfaces·Ruiqian WangYibin Ying
Jan 5, 2022·ACS Applied Materials & Interfaces·Carlota Ruiz de GalarretaJan Siegel

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Methods Mentioned

BETA
electrophoresis
biosensing
scanning electron microscopy

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