PMID: 404206Apr 1, 1977Paper

Extrapancreatic effect of glibenclamide: stimulation of duodenal insulin-releasing activity (DIRA) in man

A ZermattenJ P Felber


Experiments were performed in order to study a possible participation of gastrointestinal factors in the insulinotrophic action of glibenclamide in man. Six healthy volunteers received 5 mg glibenclamide in 50 ml saline orally. Biopsies were taken from the duodenal mucosa before and after administration of the drug. The duodenal insulin-releasing activity (DIRA) was assayed in the extracts of the biopsy material by using an in situ pancreas preparation of rat. The corresponding drug, IRI and glucose levels were measured in peripheral blood. The values of IRI correlated with both the prior elevation of DIRA and the increasing levels of the drug in the blood. These data indicate that glibenclamide might stimulate the release of gut factor(s) which, in turn, could possibly sensitize the pancrease response to the drug.


Aug 1, 1977·Diabetologia·W HeptnerJ P Felber
Aug 13, 1971·Biochimica Et Biophysica Acta·H N ChristensenI B Täljedal
Jan 1, 1973·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·J BeyerK Schöffling
Jul 1, 1974·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·A Zermatten, J P Felber
Mar 1, 1969·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·R J Mahler, O Szabo
Jul 1, 1963·The Biochemical Journal·C N HALES, P J RANDLE
Jan 26, 1963·Lancet·C N HALES, P J RANDLE
Jul 4, 1964·Lancet·N MCINTYRED S TURNER
Oct 1, 1964·The Journal of Clinical Endocrinology and Metabolism·H ELRICKY ARAI


Jan 1, 1982·European Journal of Clinical Pharmacology·L O AlmérE Wåhlin-Boll
Jan 1, 1985·European Journal of Clinical Pharmacology·L GroopF Fyhrqvist
Aug 1, 1977·Diabetologia·W HeptnerJ P Felber
Jul 1, 1980·Acta Physiologica Scandinavica·B Ahrén, I Lundquist
Apr 1, 1981·Environmental Health Perspectives·G D Niswender
Jan 1, 1981·Acta Medica Scandinavica. Supplementum·L O AlmérE Wåhlin-Boll
Jan 1, 1981·Acta Medica Scandinavica. Supplementum·A MelanderE Wåhlin-Boll

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