Extrapolating between toxicity endpoints of metal oxide nanoparticles: Predicting toxicity to Escherichia coli and human keratinocyte cell line (HaCaT) with Nano-QTTR

Ecotoxicology and Environmental Safety
Supratik KarTomasz Puzyn

Abstract

Synthesis of novel nanoparticles should always be accompanied by a comprehensive assessment of risk to human health and to ecosystem. Application of in silico models is encouraged by regulatory authorities to fill the data gaps related to the properties of nanoparticles affecting the environment and human health. Interspecies toxicity correlations provide a tool for estimation of contaminant's sensitivity with known levels of uncertainty for a diverse pool of species. We propose here first interspecies cytotoxicity correlation models between Escherichia coli (prokaryotic system) and human keratinocyte cell line (HaCaT) (eukaryotic system) to assess the discriminatory features for cytotoxicity of metal oxide nanoparticles. The nano-QTTR models can be employed for extrapolating cytotoxicity to E. coli and human keratinocyte cell line (HaCaT) for metal nanoparticles when the data for the other species are available. Informative illustrations of the contributing mechanisms of toxic action of the metal oxide nanoparticles to the HaCaT cell line as well as to the E. coli are identified from the developed nano quantitative toxicity-toxicity relationship (nano-QTTR) models.

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Citations

Jan 28, 2017·Ecotoxicology and Environmental Safety·Matija CvetnicAna Loncaric Bozic
Nov 9, 2017·International Journal of Environmental Research and Public Health·Marinda van PomerenMartina G Vijver
Jun 30, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Eleonore Fröhlich
Dec 15, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Andrey A BuglakBoris B Dzantiev
Jan 16, 2020·Nanomaterials·Irini FurxhiCraig A Poland
Jun 12, 2020·The Science of the Total Environment·Supratik Kar, Jerzy Leszczynski
Oct 24, 2020·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Chang Hee JeongSung Gu Han
May 1, 2021·Antibiotics·Ali PormohammadRaymond J Turner

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