Extrapolation Factors for Characterizing Freshwater Ecotoxicity Effects

Environmental Toxicology and Chemistry
Nicolò AurisanoPeter Fantke

Abstract

Various environmental and chemical assessment frameworks including ecological risk assessment and life cycle impact assessment aim at evaluating long-term ecotoxicity effects. Chronic test data are reported under the European Registration, Evaluation, Authorization and Restriction of Chemicals (REACH) regulation for various chemicals. However, chronic data are missing for a large fraction of marketed chemicals, for which acute test results are often available. Utilizing acute data requires robust extrapolation factors across effect endpoints, exposure durations, and species groups. We propose a decision tree based on strict criteria for curating and selecting high-quality aquatic ecotoxicity information available in REACH for organic chemicals, to derive a consistent set of generic and species group-specific extrapolation factors. Where ecotoxicity effect data are not available at all, we alternatively provide extrapolations from octanol-water partitioning coefficients as suitable predictor for chemicals with nonpolar narcosis as mode of action. Extrapolation factors range from 0.2 to 7 and are higher when simultaneously extrapolating across effect endpoints and exposure durations. Our results are consistent with previously rep...Continue Reading

References

Feb 1, 1997·Regulatory Toxicology and Pharmacology : RTP·H J KlimischU Tillmann
Apr 20, 2004·Chemical Research in Toxicology·Mark T D CroninAndrew D P Worgan
Nov 9, 2006·Environmental Toxicology and Chemistry·Shih-Hung HsiehChung-Yuan Chen
Nov 9, 2006·Environmental Toxicology and Chemistry·Jan AhlersGerrit Schüürmann
Aug 21, 2007·Environmental Toxicology and Chemistry·Kuo-Pei Tsai, Chung-Yuan Chen
Apr 2, 2008·Ecotoxicology and Environmental Safety·I GuéritC Minier
Jun 28, 2008·Ecotoxicology and Environmental Safety·Marco VighiGianna Serafina Monti
Oct 15, 2008·SAR and QSAR in Environmental Research·G PatlewiczB Aleksiev
Dec 9, 2008·SAR and QSAR in Environmental Research·C M EllisonT W Schultz
Mar 25, 2011·Environmental Health and Preventive Medicine·Yoshiharu Aizawa, Yuichiro Kudo
Jul 15, 2015·Environmental Science & Technology·Yuichi IwasakiShigeki Masunaga
Jun 30, 2016·Environmental Toxicology and Chemistry·Nienke MüllerPeter Fantke
Oct 19, 2016·Environmental Sciences Europe·Martin MayStefan Hahn
Feb 27, 2017·The Science of the Total Environment·Mikael B GustavssonThomas Backhaus
Mar 1, 2017·Environmental Science. Processes & Impacts·Mark T D Cronin
Jul 4, 2017·Environmental Toxicology and Chemistry·Erwan SaouterSerenella Sala
Aug 2, 2017·Environmental Science & Technology·A KienzlerM R Embry
Jan 20, 2018·Environmental Toxicology and Chemistry·Stefan ScholzRolf Altenburger
Mar 10, 2018·Journal of Cheminformatics·Kamel MansouriAntony J Williams
Sep 5, 2018·Environmental Toxicology and Chemistry·Peter FantkeMichael Hauschild
Oct 7, 2018·Regulatory Toxicology and Pharmacology : RTP·L S McCartyL Posthuma
May 23, 2019·Integrated Environmental Assessment and Management·Erwan SaouterDonald Versteeg
May 23, 2019·Integrated Environmental Assessment and Management·Erwan SaouterDonald Versteeg

❮ Previous
Next ❯

Citations

Oct 30, 2020·Environment International·Nicolò AurisanoPeter Fantke
Jul 1, 2021·Journal of Exposure Science & Environmental Epidemiology·Nicolò AurisanoOlivier Jolliet
May 5, 2020·Environmental Science & Technology·Hanna HolmquistGregory M Peters

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.