Extravasated platelet aggregation in liver zone 3 may correlate with the progression of sinusoidal obstruction syndrome following living donor liver transplantation: A case report

Experimental and Therapeutic Medicine
Shinichi NakanumaT Ohta

Abstract

Sinusoidal obstruction syndrome (SOS), previously known as veno-occlusive disease, is relatively rare subsequent to liver transplantation (LT). SOS refractory to medical therapy, however, can result in centrilobular fibrosis, portal hypertension and liver failure. Although sinusoidal endothelial cell damage around central venules (zone 3) occurs early in the development of SOS, the detailed mechanism of SOS development and its association with thrombocytopenia are not yet completely understood. The present report describes a patient who experienced SOS with unexplained thrombocytopenia following living donor LT. The progression of SOS resulted in graft dysfunction and the patient succumbed. The presence of platelets in the liver allograft was assayed immunohistochemically using antibody to the platelet marker cluster of differentiation 42b (platelet glycoprotein Ib). Platelet aggregates were found attached to hepatocytes along the sinusoid and within the cytoplasm of hepatocytes, particularly in zone 3. By contrast, no staining was observed in zone 1. These findings suggested that extravasated platelet aggregation in the space of Disse and the phagocytosis of platelets by hepatocytes were initiated by sinusoidal endothelial cel...Continue Reading

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Citations

Jan 29, 2016·World Journal of Gastroenterology : WJG·Matthias HartmannFuat H Saner
Apr 11, 2018·World Journal of Gastroenterology : WJG·Kazuhiro TakahashiNobuhiro Ohkohchi
Sep 30, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Magali GuffroyNasir Khan
Nov 11, 2020·Translational Research : the Journal of Laboratory and Clinical Medicine·Luca MieleErica De Candia

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