Extravascular fibrin, plasminogen activator, plasminogen activator inhibitors, and airway hyperresponsiveness

The Journal of Clinical Investigation
Scott S WagersCharles G Irvin

Abstract

Mechanisms underlying airway hyperresponsiveness are not yet fully elucidated. One of the manifestations of airway inflammation is leakage of diverse plasma proteins into the airway lumen. They include fibrinogen and thrombin. Thrombin cleaves fibrinogen to form fibrin, a major component of thrombi. Fibrin inactivates surfactant. Surfactant on the airway surface maintains airway patency by lowering surface tension. In this study, immunohistochemically detected fibrin was seen along the luminal surface of distal airways in a patient who died of status asthmaticus and in mice with induced allergic airway inflammation. In addition, we observed altered airway fibrinolytic system protein balance consistent with promotion of fibrin deposition in mice with allergic airway inflammation. The airways of mice were exposed to aerosolized fibrinogen, thrombin, or to fibrinogen followed by thrombin. Only fibrinogen followed by thrombin resulted in airway hyperresponsiveness compared with controls. An aerosolized fibrinolytic agent, tissue-type plasminogen activator, significantly diminished airway hyperresponsiveness in mice with allergic airway inflammation. These results are consistent with the hypothesis that leakage of fibrinogen and thr...Continue Reading

References

Jun 1, 1992·The American Review of Respiratory Disease·B R WiggsJ C Hogg
Jan 1, 1989·The American Review of Respiratory Disease·A L JamesJ C Hogg
Jun 15, 1986·Thrombosis Research·D F KernA B Malik
Aug 1, 1966·The American Journal of Medicine·A J Woolcock, J Read
Aug 1, 1995·American Journal of Respiratory Cell and Molecular Biology·R A PanettieriR K Murray
Aug 1, 1993·American Journal of Respiratory Cell and Molecular Biology·W SeegerH O Kalinowski
Jan 1, 1996·American Journal of Respiratory and Critical Care Medicine·P T Macklem
Aug 1, 1996·American Journal of Respiratory and Critical Care Medicine·E PizzichiniF E Hargreave
Apr 1, 1997·American Journal of Respiratory and Critical Care Medicine·K KurashimaT Kobayashi
Apr 1, 1997·American Journal of Respiratory and Critical Care Medicine·D A KaminskyC G Irvin
Feb 26, 1998·American Journal of Respiratory and Critical Care Medicine·E M WagnerM C Liu
Nov 7, 1998·American Journal of Respiratory Cell and Molecular Biology·M P McLaneR C Levitt
Dec 18, 1998·Science·M Wills-KarpD D Donaldson
Jun 29, 1999·Lung·E C GabazzaY Adachi
Jul 3, 1999·American Journal of Respiratory and Critical Care Medicine·N N Jarjour, G Enhorning
Aug 3, 1999·American Journal of Respiratory and Critical Care Medicine·T AhmedI Danta
Jan 5, 2000·American Journal of Respiratory and Critical Care Medicine·C G IrvinR J Martin
Jul 21, 2000·American Journal of Respiratory and Critical Care Medicine·D A KaminskyC G Irvin
Dec 6, 2000·The Journal of Clinical Investigation·N HattoriA F Drew
Mar 10, 2001·The Journal of Clinical Investigation·I MartyN Busso
Jun 13, 2001·American Journal of Respiratory and Critical Care Medicine·M KraftC G Irvin
Feb 2, 2002·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·H TanakaH Nagai
Apr 19, 2002·Journal of Applied Physiology·Scott WagersCharles G Irvin
Jun 19, 2002·Journal of Applied Physiology·Shinichiro TomiokaCharles G Irvin
Jun 21, 2002·Biochemical and Biophysical Research Communications·Chad K OhSeong H Cho
Jan 22, 2003·Virchows Archiv : an International Journal of Pathology·A SchmiedlJ M Hohlfeld
May 20, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K AsaiJ Yoshikawa
Jun 12, 2003·The European Respiratory Journal·K S BabuJ H Conway
Dec 9, 2003·Journal of Applied Physiology·Scott WagersJason H T Bates

❮ Previous
Next ❯

Citations

Apr 29, 2010·Current Allergy and Asthma Reports·Devendra K Agrawal, Zhifei Shao
Oct 25, 2006·Proceedings of the National Academy of Sciences of the United States of America·Patricia C FulkersonMarc E Rothenberg
Sep 28, 2007·Proceedings of the National Academy of Sciences of the United States of America·Prescott G WoodruffJohn V Fahy
Jan 30, 2013·The Journal of General Physiology·Seema MukherjeeJose F Perez-Zoghbi
May 12, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Suil Kim, Jay A Nadel
Nov 10, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·John F AlcornYvonne M W Janssen-Heininger
Oct 11, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jaime M CyphertBeverly H Koller
Mar 17, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Kazuhiko ShinagawaFrancis J Castellino
Jul 10, 2007·American Journal of Respiratory and Critical Care Medicine·Wayne MitznerClarke Tankersley
Nov 4, 2006·American Journal of Respiratory and Critical Care Medicine·Kazuhiko ShinagawaFrancis J Castellino
Jan 27, 2007·American Journal of Respiratory and Critical Care Medicine·Lennart K A LundbladJason H T Bates
Sep 1, 2007·American Journal of Respiratory and Critical Care Medicine·John F AlcornCharles G Irvin
Oct 27, 2007·American Journal of Respiratory and Critical Care Medicine·Jason H T BatesCharles G Irvin
Jul 20, 2010·American Journal of Respiratory and Critical Care Medicine·Livia A VeressCarl W White
Aug 17, 2010·American Journal of Respiratory and Critical Care Medicine·Takehiro TakagiEsteban C Gabazza
Nov 17, 2012·American Journal of Respiratory and Critical Care Medicine·Tetsuji TakabayashiRobert P Schleimer
Jun 24, 2006·American Journal of Respiratory Cell and Molecular Biology·Eric K ChuJeffrey M Drazen
Jun 24, 2006·American Journal of Respiratory Cell and Molecular Biology·Jessica S SiegleRakesh K Kumar
May 14, 2008·American Journal of Respiratory Cell and Molecular Biology·Kazuhiro ItoRakesh K Kumar
Jan 26, 2010·American Journal of Respiratory Cell and Molecular Biology·Taher NassarAbd Al-Roof Higazi
May 28, 2011·American Journal of Respiratory Cell and Molecular Biology·Taher NassarAbd Al-Roof Higazi
Jul 3, 2004·The Journal of Clinical Investigation·Michael A Matthay, John A Clements
Nov 16, 2006·Blood·Toshihiko NishimuraLawrence L K Leung
Nov 23, 2012·Journal of Biomedical Science·Jyh-Hwa KauHsin-Hou Chang
Feb 13, 2013·Respiratory Research·Dhananjay DesaiChristopher E Brightling
Apr 24, 2009·Proceedings of the American Thoracic Society·Homer A Boushey
Apr 24, 2009·Proceedings of the American Thoracic Society·Charles G Irvin, Jason H T Bates
Mar 1, 2011·FEBS Letters·Florence BrellierRuth Chiquet-Ehrismann
Jun 30, 2015·American Journal of Respiratory Cell and Molecular Biology·Michael SchuligaAlastair G Stewart
Dec 21, 2010·Seminars in Arthritis and Rheumatism·Anna Ludwicka-BradleyGalina S Bogatkevich
Nov 4, 2015·The Journal of Allergy and Clinical Immunology·Stephane EsnaultNizar N Jarjour
Jun 30, 2007·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·E PretoriusE Smit
Apr 9, 2014·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C Page, S Pitchford
Sep 24, 2004·Trends in Pharmacological Sciences·Nieves FernándezMariano Sánchez Crespo
Sep 26, 2015·American Journal of Respiratory Cell and Molecular Biology·Jennifer A MitchelJin-Ah Park
Dec 26, 2013·Allergology International : Official Journal of the Japanese Society of Allergology·Masaaki TodaJohn Morser
Dec 17, 2005·American Journal of Human Genetics·Dawn L DemeoEdwin K Silverman
Sep 8, 2010·Biochemical and Biophysical Research Communications·Zhongcai MaDavid Paek
Mar 29, 2016·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S Bazan-SochaA Undas
Mar 10, 2010·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D EwenJ K Shute

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
lavage

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Asthma : Official Journal of the Association for the Care of Asthma
F J H BrimsJanis K Shute
The Journal of Clinical Investigation
Michael A Matthay, John A Clements
Biochemical and Biophysical Research Communications
Chad K OhSeong H Cho
© 2022 Meta ULC. All rights reserved