PMID: 6169658Mar 15, 1981Paper

Extravascular natural cytotoxicity in man: Anti-K562 activity of lymph-node and tumour-infiltrating lymphocytes

International Journal of Cancer. Journal International Du Cancer
M Moore, B M Vose

Abstract

A major distinction is reported between the cytolytic activity of peripheral blood lymphocytes (PBL) and that of lymph-node and tumour-infiltrating lymphocytes (TIL) against targets of the NK-sensitive K562 cell line in short-term 51Cr release assays. In the PBL of normal donors and lung cancer patients in whom disease was advanced anti-K562 reactivity, though variable, was consistently detectable and this activity could be augmented to a similar extent in patients and controls by treatment of effectors with exogenous interferon (IF). By contrast anti-K562 activity in lymph-node cells (LNC) and TIL was virtually absent and significant levels could not be induced by exposure to IF. This activity was not attributable to coexistent suppressor cells for NK function since admixture of LNC and TIL with normal PBL failed to modulate K562 killing by the latter. The results imply that K562-reactive NK cells and their precursors may frequently be present at sub-threshold levels in the lymph nodes of tumour-bearing patients and a similar explanation could account for the inactivity of TIL. However, in the latter situation, actively-induced NK dysfunction in situ incapable of regeneration by IF, and attributable to as yet undefined tumour-...Continue Reading

References

Nov 15, 1979·International Journal of Cancer. Journal International Du Cancer·B M Vose, M Moore
Nov 1, 1977·European Journal of Immunology·B M VoseE Klein
Jan 15, 1978·International Journal of Cancer. Journal International Du Cancer·O EreminJ Ashby
Sep 15, 1978·Cellular Immunology·M A Kall, H S Koren
Apr 15, 1977·International Journal of Cancer. Journal International Du Cancer·T BakácsE Klein
Jan 15, 1978·International Journal of Cancer. Journal International Du Cancer·O EreminJ P Stephens
Feb 1, 1979·International Journal of Cancer. Journal International Du Cancer·L C AnderssonC G Gahmberg
Jun 1, 1979·British Journal of Cancer·K Moore, M Moore
Jan 1, 1979·Scandinavian Journal of Immunology·E SakselaK Cantell
Nov 15, 1976·International Journal of Cancer. Journal International Du Cancer·H F Pross, M G Baines
May 1, 1977·The Journal of Experimental Medicine·O HallerH Wigzell
Jan 1, 1977·International Archives of Allergy and Applied Immunology·O EreminD Franks
Jan 1, 1976·International Archives of Allergy and Applied Immunology·O EreminR R Coombs
May 15, 1980·International Journal of Cancer. Journal International Du Cancer·A MantovaniC Mangioni
Mar 1, 1980·British Journal of Cancer·M Moore, M R Potter

❮ Previous
Next ❯

Citations

Jan 1, 1983·Cancer Metastasis Reviews·M Introna, A Mantovani
Jan 1, 1993·Cancer Immunology, Immunotherapy : CII·A M MalyginT Timonen
Feb 1, 1994·International Journal of Immunopharmacology·N TanakaK Orita
Jul 30, 1991·International Journal of Cancer. Journal International Du Cancer·D A LoefflerG H Heppner
Oct 1, 1989·Pathology, Research and Practice·E B Bröcker
Jan 1, 1987·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·K Vinzenz, M Micksche
Oct 1, 1993·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·I YoshinoK Nomoto
Jan 15, 1987·International Journal of Cancer. Journal International Du Cancer·M SarzottiG R Klimpel
Jul 1, 1988·Journal of Surgical Oncology·H YaitaK Nomoto
Jul 1, 1985·Scandinavian Journal of Immunology·S E ChristmasM Moore
Oct 1, 1986·Journal of Maxillofacial Surgery·K Vinzenz, M Micksche
Jan 1, 1983·Scandinavian Journal of Immunology·I Kimber, M Moore
Jan 1, 1986·Critical Reviews in Clinical Laboratory Sciences·N E Kay
Oct 1, 1982·Journal of Clinical Immunology·J C Roder, H F Pross

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.