PMID: 2116529Jul 1, 1990Paper

Extreme differences in charge changes during protein evolution

Journal of Molecular Evolution
J A LeunissenW W de Jong

Abstract

The maintenance of a proper distribution of charged amino acid residues might be expected to be an important factor in protein evolution. We therefore compared the inferred changes in charge during the evolution of 43 protein families with the changes expected on the basis of random base substitutions. It was found that certain proteins, like the eye lens crystallins and most histones, display an extreme avoidance of changes in charge. Other proteins, like phospholipase A2 and ferredoxin, apparently have sustained more charged replacements than expected, suggesting a positive selection for changes in charge. Depending on function and structure of a protein, charged residues apparently can be important targets for selective forces in protein evolution. It appears that actual biased codon usage tends to decrease the proportion of charged amino acid replacements. The influence of nonrandomness of mutations is more equivocal. Genes that use the mitochondrial instead of the universal code lower the probability that charge changes will occur in the encoded proteins.

References

Jan 1, 1977·Annual Review of Biochemistry·R D Kornberg
Jan 1, 1977·Annual Review of Biochemistry·A C WilsonT J White
Sep 29, 1978·Science·M F Perutz
Dec 31, 1975·Journal of Molecular Evolution·E Zuckerkandl
Jan 1, 1986·Annual Review of Biophysics and Biophysical Chemistry·B H HonigR F Flewelling
Mar 22, 1985·Science·D J Lipman, W R Pearson
Jan 1, 1987·Journal of Molecular Evolution·G Preparata, C Saccone
Jan 1, 1987·Journal of Molecular Evolution·P Perrin, G Bernardi
Dec 1, 1988·Journal of Molecular Evolution·G BernardiG Bernardi
Mar 1, 1988·Experimental Eye Research·C SlingsbyT L Blundell
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·N Sueoka
Dec 20, 1986·Journal of Molecular Biology·A TardieuM Delaye
Aug 5, 1987·Journal of Molecular Biology·S MillerC Chothia
Jan 1, 1986·Nucleic Acids Research·T MaruyamaT Ikemura
Jan 1, 1985·Annual Review of Biophysics and Biophysical Chemistry·J B Matthew
Feb 15, 1985·European Journal of Biochemistry·S O StapelW W de Jong
Aug 30, 1985·Science·G D RoseM H Zehfus
Jan 1, 1971·Journal of Molecular Evolution·R E Dickerson
Aug 1, 1984·Quarterly Reviews of Biophysics·A Warshel, S T Russell
Aug 25, 1983·Journal of Molecular Biology·D J Barlow, J M Thornton
May 5, 1982·Journal of Molecular Biology·J Kyte, R F Doolittle
Oct 29, 1981·Nature·A Wada, H Nakamura

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Citations

Jan 14, 2010·Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life·J Dennis PollackDennis K Pearl
Jul 3, 1998·International Journal of Biological Macromolecules·R H SmuldersW W de Jong
Sep 15, 1995·European Journal of Biochemistry·R H SmuldersW W De Jong
Jan 1, 1995·World Journal of Microbiology & Biotechnology·J K Kristjánsson, G O Hreggvidsson

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