PMID: 6573945Jun 1, 1983

Extreme hypodiploidy in a case of myelomonocytic crisis of chronic myelogenous leukemia

Cancer Genetics and Cytogenetics
B Pedersen, A M Boesen


Two cytogenetically distinct populations of marrow cells were observed in a 28-year-old woman who developed a fulminant blastic crisis (BC) of chronic myelogenous leukemia (CML) after only 1 year in the chronic phase: one population with 35-36 chromosomes, the other showing 66-72 chromosomes. Cytochemical investigation demonstrated a myelomonocytic type of BC. Chromosome banding and correlation analysis of the mean karyotypes of the two populations showed that a close relationship existed between them, indicating that one population had developed from the other. The cytogenetic evidence suggests but does not prove that the cells with triploid chromosome numbers developed from the extremely hypodiploid population by duplication of the chromosome complement. The extreme cytogenetic diversity of both populations indicates that each was undergoing further cytogenetic evolution.


Jan 1, 1973·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·C Y LiL T Yam
Aug 1, 1981·Cancer Genetics and Cytogenetics·S E PetersenU Friedrich
Jan 1, 1981·Human Genetics·N B Atkin, M C Baker


Mar 15, 1985·Cancer Genetics and Cytogenetics·S MisawaJ R Testa
Oct 1, 1985·Cancer Genetics and Cytogenetics·K OhtakiA A Sandberg
Apr 1, 1991·Cancer Genetics and Cytogenetics·C SreekantaiahA A Sandberg
Jan 1, 1988·Leukemia Research·R S VermaM Coleman

Related Concepts

Aneuploid Cell
Chromosome Banding
Leukemia, Monocytic, Chronic
Acute Myeloid Leukemia, M1

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