Extreme Neuroplasticity of Hippocampal CA1 Pyramidal Neurons in Hibernating Mammalian Species

Frontiers in Neuroanatomy
John M Horowitz, B A Horwitz

Abstract

In awake and behaving mammals (with core and brain temperatures at ~37°C), hippocampal neurons have anatomical and physiological properties that support formation of memories. However, studies of hibernating mammalian species suggest that as hippocampal temperature falls to values below ~10°C, CA1 neurons lose their ability to generate long term potentiation (LTP), a basic form of neuroplasticity. That is, the persistent increase in CA3-CA1 synaptic strength following high-frequency stimulation of CA3 fibers (the hallmark of LTP generation at 37°C) is no longer observed at low brain temperatures although the neurons retain their ability to generate action potentials. In this review, we examine the relationship of LTP to recently observed CA1 structural changes in pyramidal neurons during the hibernation cycle, including the reversible formation of hyperphosphorylated tau. While CA1 neurons appear to be stripped of their ability to generate LTP at low temperatures, their ability to still generate action potentials is consistent with the longstanding proposal that they have projections to neural circuits controlling arousal state throughout the hibernation cycle. Recent anatomical studies significantly refine and extend previous ...Continue Reading

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Citations

May 16, 2019·International Journal of Molecular Sciences·Giacomo Gattoni, Graziella Bernocchi
Jul 25, 2019·Frontiers in Neuroanatomy·Mandy Sonntag, Thomas Arendt
Oct 17, 2019·Frontiers in Neuroanatomy·Julie RoyoFabien Pifferi
Dec 15, 2020·Biological Reviews of the Cambridge Philosophical Society·Zhe ShiXin-Min Liu
May 21, 2020·Cerebral Cortex Communications·Mamen Regalado-ReyesGonzalo León-Espinosa
Jul 31, 2021·Scientific Reports·Christina F de Veij MestdaghRonald E van Kesteren
Aug 27, 2021·Metabolites·Alexander Myrka, Leslie Buck

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