PMID: 7008182Sep 1, 1980Paper

Extreme potassium loss in a patient with severe graft versus host disease

Scandinavian Journal of Haematology
G J TricotH L Haak

Abstract

A 19-year-old male, suffering from post-hepatitis aplastic anaemia, was transplanted with bone marrow cells from his HLA-identical, MLC non-reactive brother. Haematological recovery ensued, but the patient also developed grade IV graft-versus-host disease (GVHD). In addition to involvement of skin, liver and gut, the kidney seemed affected by GVHD since the patient has hypokalaemia and severe hyperkaluria. Other causes of urinary potassium loss were excluded. The amount of potassium loss correlated well with the severity of the GVH-reaction. Although coagulation disorders prohibited a kidney biopsy, the clinical course suggested GVHD to be the cause of the urinary potassium loss.

References

May 27, 1976·The New England Journal of Medicine·R J WhitleyC A Alford
Apr 17, 1975·The New England Journal of Medicine·E ThomasC D Buckner
Mar 26, 1977·British Medical Journal·H F Guiot, R Furth
Mar 18, 1972·Lancet·M H TattersallA S Spiers

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