Extreme selection strategies in gene mapping studies of oligogenic quantitative traits do not always increase power

Human Heredity
D B AllisonRobert C Elston

Abstract

It is well known that obtaining adequate statistical power to detect linkage to or association with genes for complex quantitative traits can be very difficult. In response, investigators have developed a number of power-enhancing strategies that consider restraints such as genotyping (and/or phenotyping) costs. In the context of both association and sib pair linkage studies of quantitative traits, one of the most widely discussed techniques is the selective sampling of phenotypically extreme individuals. Several papers have demonstrated that such extreme sampling can markedly increase power (under certain circumstances). However, the parenthetical phrase in the previous sentence has generally not been made explicit and it appears to be implied that the more phenotypically extreme the individuals, the more power one has. In this paper, we show by simulation that this is not true under all circumstances. In particular, we show that under oligogenic models, where some biallelic quantitative trait loci (QTLs) have markedly asymmetric allele frequencies and large mean displacement among genotypes, and others have less asymmetric allele frequencies and smaller mean displacement among genotypes, power to detect linkage to or associat...Continue Reading

Citations

Jul 18, 2002·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·C M Bulik, D B Allison
Apr 14, 2007·Annual Review of Nutrition·Cynthia M BulikPatrick F Sullivan
Feb 17, 2001·American Journal of Respiratory and Critical Care Medicine·A J SandfordP D Paré
Mar 23, 2005·Genetics·Saunak SenGary A Churchill
Aug 5, 2011·International Journal of Chronic Obstructive Pulmonary Disease·Tillie-Louise HackettAndrew J Sandford
Jan 22, 2005·Genetic Epidemiology·Jin P Szatkiewicz, Eleanor Feingold
Jun 10, 2004·Atherosclerosis·Alfredo MorabiaT Conrad Gilliam
Apr 28, 2006·American Journal of Human Genetics·Mingyao LiGonçalo R Abecasis
May 12, 2001·American Journal of Human Genetics·G R AbecasisL R Cardon
Jul 6, 2014·American Journal of Human Genetics·Seunggeung LeeXihong Lin
May 20, 1999·American Journal of Human Genetics·D B AllisonE R Martin
Feb 22, 2002·Theoretical Population Biology·E Feingold
Aug 23, 2006·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Andréa Poyastro PinheiroCynthia M Bulik
Nov 24, 2006·Genetic Epidemiology·Christopher W Bartlett, Veronica J Vieland
Feb 1, 2008·The International Journal of Eating Disorders·Walter H KayeIan Jones
Jun 27, 2002·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·B Rannala
Sep 21, 2006·Physiological Genomics·Guilherme J M RosaArtur J M Rosa
Nov 1, 2017·Canine Genetics and Epidemiology·Meenakshi MukherjeeJianbo Yao
Aug 3, 2020·European Journal of Human Genetics : EJHG·Linhai ZhaoSuzanne M Leal
Aug 10, 2004·Epidemiologia e psichiatria sociale·Cynthia M Bulik, Federica Tozzi
Jun 23, 2004·CNS Spectrums·Cynthia M Bulik, Federica Tozzi
Jun 20, 1998·Science·A G Comuzzie, D B Allison

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.