Extreme Th1 bias of invariant Valpha24JalphaQ T cells in type 1 diabetes

Nature
S B WilsonD A Hafler

Abstract

Type 1 diabetes (insulin-dependent diabetes mellitus, IDDM) is a disease controlled by the major histocompatibility complex (MHC) which results from T-cell-mediated destruction of pancreatic beta-cells. The incomplete concordance in identical twins and the presence of autoreactive T cells and autoantibodies in individuals who do not develop diabetes suggest that other abnormalities must occur in the immune system for disease to result. We therefore investigated a series of at-risk non-progressors and type 1 diabetic patients (including five identical twin/triplet sets discordant for disease). The diabetic siblings had lower frequencies of CD4-CD8- Valpha24JalphaQ+ T cells compared with their non-diabetic sibling. All 56 Valpha24JalphaQ+ clones isolated from the diabetic twins/triplets secreted only interferon (IFN)-gamma upon stimulation; in contrast, 76 of 79 clones from the at-risk non-progressors and normals secreted both interleukin (IL)-4 and IFN-gamma. Half of the at-risk non-progressors had high serum levels of IL-4 and IFN-gamma. These results support a model for IDDM in which Thl-cell-mediated tissue damage is initially regulated by Valpha24JalphaQ+ T cells producing both cytokines; the loss of their capacity to secret...Continue Reading

References

Feb 1, 1996·Immunology Today·A P Vicari, A Zlotnik
Oct 1, 1996·The Journal of Experimental Medicine·D R BrownS L Reiner
Oct 31, 1996·Nature·A K AbbasA Sher
Nov 1, 1996·International Immunology·J M GombertA Herbelin
Feb 3, 1997·The Journal of Experimental Medicine·M G von Herrath, M B Oldstone
Jan 1, 1997·Annual Review of Immunology·A BendelacJ H Roark
Jul 7, 1997·The Journal of Experimental Medicine·M ExleyS Porcelli

❮ Previous
Next ❯

Citations

Dec 23, 1998·European Journal of Immunology·C CouedelM Bonneville
Jun 8, 1999·European Journal of Immunology·A ShamshievG De Libero
Oct 30, 1999·European Journal of Immunology·F TilloyO Lantz
Nov 11, 1999·European Journal of Immunology·K J HammondD I Godfrey
Sep 25, 2001·The Journal of Pathology·R J Glynne, S R Watson
Nov 28, 2000·European Journal of Immunology·F M SpadaS A Porcelli
Jan 5, 2002·Diabetes/metabolism Research and Reviews·L D Poulton, A G Baxter
Oct 25, 2002·Diabetes/metabolism Research and Reviews·Guido MeierhoffNanette C Schloot
Feb 10, 2000·Springer Seminars in Immunopathology·L R Wedderburn, P Woo
Sep 7, 2005·Diabetologia·K BuschardP Fredman
Aug 26, 2010·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Arnd HeiligenhausGerhild Wildner
May 21, 2005·Virchows Archiv : an International Journal of Pathology·Hideki FujiiKenji Kaneda
Jul 25, 2012·Clinical and Experimental Medicine·Jan Novak, Lucie Novakova
Apr 18, 2008·Current Allergy and Asthma Reports·Philippe Stock, Omid Akbari
Mar 30, 2005·Current Diabetes Reports·Brygida C Bisikirska, Kevan C Herold
Nov 26, 1999·Life Sciences·V Kumar, E Sercarz
Aug 26, 1998·Immunology Today·S A PorcelliM B Brenner
Oct 24, 1998·Immunology Today·K V SalojinT L Delovitch
Apr 1, 2004·Endocrinology and Metabolism Clinics of North America·Timothy I M Tree, Mark Peakman
Mar 22, 2002·Nature Reviews. Immunology·A BendelacJ F Kearney
Feb 19, 2009·Immunology and Cell Biology·Marie T Fletcher, Alan G Baxter
May 4, 2004·Nature Immunology·Yoshihiro HayakawaMark J Smyth
Oct 28, 2006·Nature Reviews. Immunology·Dale T Umetsu, Rosemarie H DeKruyff
Jan 27, 2011·Nature Reviews. Immunology·Stuart P BerzinsAlan G Baxter
Nov 20, 2002·British Journal of Haematology·Weihua ZengNeal S Young
Mar 8, 2002·Clinical and Experimental Immunology·A KoreckA Dobozy
Jul 6, 2001·Scandinavian Journal of Immunology·J F Bach
Jun 10, 2004·Immunology and Cell Biology·Stuart P BerzinsDale I Godfrey
Aug 4, 2001·The New England Journal of Medicine·A Davidson, B Diamond
Mar 17, 2006·The New England Journal of Medicine·Hong Jiang, Leonard Chess
Oct 7, 2008·Proceedings of the National Academy of Sciences of the United States of America·Hongyan DiaoToshimitsu Uede

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.