Extreme warfarin sensitivity in siblings associated with multiple cytochrome P450 polymorphisms

American Journal of Hematology
A R TabriziB D Freeman

Abstract

Warfarin use is complicated by an erratic dose response. Warfarin is metabolized by two distinct subfamilies of the cytochrome P450 (CYP) complex. We describe two siblings with extreme sensitivity to warfarin who share an unusual CYP genotype. These individuals illustrate both the importance of genetics in influencing the metabolism of warfarin as well as the potential utility of genetic testing as a guide to prescribing this medication.

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Citations

Jun 4, 2011·Journal of Thrombosis and Thrombolysis·Mirjana K KovacDragica P Radojkovic
Oct 31, 2002·Advanced Drug Delivery Reviews·Hong-Guang XieC Michael Stein
Sep 20, 2006·The Pharmacogenomics Journal·M Wadelius, M Pirmohamed
Oct 29, 2004·Journal of Clinical Pathology·J P Hanley
Oct 31, 2016·Genomics, Proteomics & Bioinformatics·Shabbir AhmedShu-Qing Chen
Aug 22, 2003·The Pharmacogenomics Journal·H Takahashi, H Echizen
Apr 16, 2019·Pharmacogenomics·Antigoni ChaidaroglouDimitrios Degiannis
Sep 14, 2006·Pharmacological Reviews·Sharon J Gardiner, Evan J Begg

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