Extreme weather events and environmental contamination are associated with case-clusters of melioidosis in the Northern Territory of Australia

International Journal of Epidemiology
Allen C ChengB J Currie


Melioidosis, the infection due to the environmental organism Burkholderia pseudomallei, is endemic to northern Australia and South East Asia. It is associated with exposure to mud and pooled surface water, but environmental determinants of this disease are poorly understood. We defined case-clusters in northern Australia, determined their contribution to the observed rate of melioidosis, and explored clinical features and associated environmental factors. Using geographical information systems data, we examined clustering of melioidosis cases in time and geographical space in the Top End of the Northern Territory of Australia between 1990 and 2002 using a scan statistic. DNA macrorestriction analysis, resolved by pulsed field gel electrophoresis, was performed on isolates from patients. We defined five case-clusters involving 27 patients that occurred within 7-28 days and/or a radius of 100-300 km. Clustered cases were associated with extreme weather events or environmental contamination; no difference in the clinical pattern of disease was noted from other patients not involved in clusters. Isolates from patients linked to environmental contamination were caused by isolates with similar DNA macrorestriction patterns, but isola...Continue Reading


Jan 1, 1991·Transactions of the Royal Society of Tropical Medicine and Hygiene·D A Dance
May 1, 1986·Australian Veterinary Journal·P J KettererA D Thomas
Sep 1, 1985·Journal of Clinical Microbiology·N LeeW C Tsai
Oct 1, 1994·International Journal of Epidemiology·Y SuputtamongkolN J White
Apr 1, 1994·Journal of Clinical Pathology·A L WalshN J White
May 15, 1997·Hospital Practice·U ChodimellaG W Rutecki
Sep 16, 1998·American Journal of Public Health·M KulldorffC R Key
Feb 16, 2000·Acta Tropica·B J CurrieM J Mayo
Oct 26, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·B J CurrieV L Krause
May 28, 2003·Lancet·N J White
Sep 27, 2003·Water Research·Kay Howard, Timothy J J Inglis
Jan 15, 2004·Emerging Infectious Diseases·Bart J Currie, Susan P Jacups
Feb 8, 2005·Journal of Clinical Microbiology·Viseth NgauyGeorge Crawford

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Dec 1, 2017·Current Tropical Medicine Reports·Adam J Merritt, Timothy J J Inglis
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Oct 11, 2017·The American Journal of Tropical Medicine and Hygiene·Catherine E L OngDirek Limmathurotsakul
Aug 31, 2006·Current Opinion in Infectious Diseases·Sharon J Peacock
Dec 23, 2008·The British Journal of Radiology·M MuttarakC Sivasomboon
May 1, 2009·Clinical and Vaccine Immunology : CVI·Patrick N A HarrisRobert E Norton
Apr 25, 2015·Experimental Biology and Medicine·Susanna K P LauPatrick C Y Woo
Feb 13, 2016·The Medical Journal of Australia·Simon QuiltyMichael F McVeigh
Nov 3, 2017·The Medical Journal of Australia·James D StewartJosh Hanson
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Apr 16, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David L PatersonPatrick N A Harris
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Aug 31, 2020·Current Dermatology Reports·R Fathy, Misha Rosenbach
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Sep 21, 2019·Emerging Infectious Diseases·Irene GuendelEsther M Ellis
Mar 13, 2020·Clinical Microbiology Reviews·I GassiepR Norton
Jul 1, 2011·Reviews on Environmental Health·Graeme R Zosky
Feb 2, 2018·Nature Reviews. Disease Primers·W Joost WiersingaDirek Limmathurotsakul
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