Extremely high conservation in the untranslated region as well as the coding region of CNP mRNAs throughout elasmobranch species

General and Comparative Endocrinology
S HyodoJohn A Donald

Abstract

C-type natriuretic peptide (CNP) is a crucial osmoregulatory hormone in elasmobranchs, participating in salt secretion and drinking. In contrast to teleosts and tetrapods in which the NP family is composed of a group of structurally related peptides, we have shown that CNP is the sole NP in sharks. In the present study, CNP cDNAs were cloned from four species of batoids, another group of elasmobranchs. The cloned batoid CNP precursors contained a plausible mature peptide of 22 amino acid residues that is identical to most shark CNP-22s, but five successive amino acids were consistently deleted in the prosegment compared with shark precursors, supporting the diphyletic classification of sharks and rays. In addition, molecular phylogenetic trees of CNP precursors were consistent with a diphyletic interpretation. Except for the deletion, the nucleotide and deduced amino acid sequences of the CNP cDNAs are extremely well-conserved among all elasmobranch species, even between sharks and rays. Surprisingly, high conservation is evident not only for the coding region, but also for the untranslated regions. It is most likely that the high conservation is due to the low nucleotide substitution rate in the elasmobranch genome, and high s...Continue Reading

References

May 1, 1992·The Journal of Endocrinology·C BjenningN Hazon
Jun 1, 1992·Computer Applications in the Biosciences : CABIOS·D T JonesJ M Thornton
Jan 1, 1993·The Journal of Experimental Zoology·D H EvansJ N Forrest
Jun 1, 1996·Kidney International·P SilvaF H Epstein
Jan 13, 2000·Biochemical and Biophysical Research Communications·E Gay, S Babajko
Apr 8, 2000·General and Comparative Endocrinology·Y AmemiyaH Kawauchi
Feb 5, 2003·Molecular Phylogenetics and Evolution·Christophe J DouadyMichael J Stanhope
Aug 2, 2003·Proceedings of the National Academy of Sciences of the United States of America·Koji InoueYoshio Takei
Aug 13, 2003·Bioinformatics·Fredrik Ronquist, John P Huelsenbeck
Dec 10, 2003·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Neil HazonCraig E Franklin
Jan 22, 2004·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·T Toop, J A Donald
Mar 17, 2004·Molecular Phylogenetics and Evolution·Christopher J WinchellJon Mallatt

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Citations

Dec 17, 2008·General and Comparative Endocrinology·Taro WatanabeYoshio Takei
May 13, 2008·General and Comparative Endocrinology·Keven R Johnson, Kenneth R Olson
Feb 26, 2008·General and Comparative Endocrinology·Sofie Trajanovska, John A Donald

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