Extremely hypotrophic newborn of mother with systemic lupus erythematosus and antiphospholipid syndrome

Lupus
A MockováZ Ulčová-Gallová

Abstract

The case presented describes a high-risk pregnancy of a woman with systemic lupus erythematosus (SLE) with multiple lesions of central nervous system (CNS), vasculitis, secondary epilepsy and antiphospholipid syndrome (APS). At gestational age 28 weeks and 3 days the pregnancy was urgently terminated via caesarean section and an extremely hypotrophic immature newborn with a birth weight of 580 g was born. The high disease activity in the mother at the time of conception and the histologically proven chronic placental insufficiency due to APS are presumably the causes for the extensive hypotrophy of the neonate. The significant comorbidity of the newborn, including respiratory distress syndrome, bronchopulmonary dysplasia, necrotizing enterocolitis, osteopathy of prematurity, transient hypothyroidism and hypocortisolism, vesicoureteral reflux, and hypertonic-hyperexcitation syndrome complicated his three-month stay in NICU. A positive titre of transplacentally transferred anticardiolipin and anti-β2 glycoprotein antibody was detected in the child and persisted through the following 30 months. During the three-year follow-up, significantly delayed neuropsychological development with microcephaly (-4 SD) and short stature of the c...Continue Reading

References

Feb 1, 1991·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J P Hayslett
Mar 5, 2002·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Anais TendronS Decramer
Oct 17, 2003·The New England Journal of Medicine·Melissa R ArbuckleJohn B Harley
Nov 22, 2005·Clinical & Developmental Immunology·J ChapmanA D Korczyn
Dec 13, 2006·Lupus·A TincaniUNKNOWN Pregancy Study Group of Italian Socitety of Rheumatology
Mar 4, 2008·Arthritis and Rheumatism·R NacinovichA Tincani
May 19, 2010·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Kazumichi FujiokaMasafumi Matsuo
Dec 30, 2011·Journal of Autoimmunity·Laura AndreoliAngela Tincani
May 17, 2012·Annals of the Rheumatic Diseases·Arsene MekinianMarie-Claire Boffa
Aug 14, 2012·Expert Review of Clinical Immunology·George Stojan, Alan N Baer

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray
enzyme-linked immunosorbent assays

Related Concepts

Related Feeds

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.

Addison Disease

Addison's disease, also known as primary adrenal insufficiency and hypocortisolism, is a long-term endocrine disorder in which the adrenal glands do not produce enough steroid hormones. Discover the latest research on Addison's disease here.