Abstract
The case presented describes a high-risk pregnancy of a woman with systemic lupus erythematosus (SLE) with multiple lesions of central nervous system (CNS), vasculitis, secondary epilepsy and antiphospholipid syndrome (APS). At gestational age 28 weeks and 3 days the pregnancy was urgently terminated via caesarean section and an extremely hypotrophic immature newborn with a birth weight of 580 g was born. The high disease activity in the mother at the time of conception and the histologically proven chronic placental insufficiency due to APS are presumably the causes for the extensive hypotrophy of the neonate. The significant comorbidity of the newborn, including respiratory distress syndrome, bronchopulmonary dysplasia, necrotizing enterocolitis, osteopathy of prematurity, transient hypothyroidism and hypocortisolism, vesicoureteral reflux, and hypertonic-hyperexcitation syndrome complicated his three-month stay in NICU. A positive titre of transplacentally transferred anticardiolipin and anti-β2 glycoprotein antibody was detected in the child and persisted through the following 30 months. During the three-year follow-up, significantly delayed neuropsychological development with microcephaly (-4 SD) and short stature of the c...Continue Reading
References
Feb 1, 1991·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J P Hayslett
Sep 1, 1974·The Journal of Pediatrics·C J CotéR J Pickering
Oct 1, 1984·The Journal of Pediatrics·D B DeWitteM J Maisels
Mar 5, 2002·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Anais TendronS Decramer
Oct 17, 2003·The New England Journal of Medicine·Melissa R ArbuckleJohn B Harley
Nov 16, 2004·Lupus·F NeriA Tincani
Nov 22, 2005·Clinical & Developmental Immunology·J ChapmanA D Korczyn
Jan 20, 2006·Journal of Thrombosis and Haemostasis : JTH·S MiyakisS A Krilis
Apr 26, 2006·Lupus·D Shepshelovich, Y Shoenfeld
Dec 13, 2006·Lupus·A TincaniUNKNOWN Pregancy Study Group of Italian Socitety of Rheumatology
Feb 8, 2007·Lupus·J SpiegelM H Weisman
Mar 4, 2008·Arthritis and Rheumatism·R NacinovichA Tincani
Jun 10, 2008·Lupus·M B UrowitzE Silverman
Dec 17, 2009·Lupus·A D AskanaseJ P Buyon
May 19, 2010·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Kazumichi FujiokaMasafumi Matsuo
Oct 26, 2010·Annals of the Rheumatic Diseases·Laura AndreoliAngela Tincani
Jan 20, 2011·Rheumatology·Chee-Seng YeeCaroline Gordon
Dec 22, 2011·Seminars in Thrombosis and Hemostasis·Gili KenetUlrike Nowak-Göttl
Dec 30, 2011·Journal of Autoimmunity·Laura AndreoliAngela Tincani
May 17, 2012·Annals of the Rheumatic Diseases·Arsene MekinianMarie-Claire Boffa
Aug 14, 2012·Expert Review of Clinical Immunology·George Stojan, Alan N Baer
Nov 10, 2012·Arthritis Care & Research·Wendy MarderEmily C Somers