Extremely low frequency magnetic fields regulate differentiation of regulatory T cells: Potential role for ROS-mediated inhibition on AKT

Bioelectromagnetics
Ruijing TangTingting Wang

Abstract

Our previous studies showed that extremely low frequency magnetic fields (ELF-MFs) inhibited tumor growth and change proportion of splenic regulatory T cells (Treg cells). Here, we focus on the effect of ELF-MFs on lung metastatic melanoma mouse model and the regulatory mechanism of ELF-MFs on the differentiation of Treg cells. Tumor-bearing mice were exposed to sham ELF-MFs and ELF-MFs (0.4 T, 7.5 Hz) 2 h/day for 27 days. Metastatic tumor burden of lung was significantly decreased after ELF-MF treatment. Compared to the control group, expressions of matrix metalloproteinase (MMP2, MMP9) and forkhead box P3 (Foxp3) in lung nodules significantly decreased in the ELF-MF group. Moreover, in vitro, after stimulated with anti-CD3, anti-CD28 antibodies and transforming growth factor-β (TGF-β) and treated with ELF-MFs for 2 h, expression of Foxp3 in total T cells was significantly decreased. Differentiation rate of Treg cells was inhibited from 32.0% to 22.1% by ELF-MFs. Furthermore, reactive oxygen species (ROS) was increased and phospho-serine/threonine protein kinase (p-AKT) was inhibited in both T cells and Jurkat cells. ROS scavenger N-acetyl-l-cysteine reversed inhibition of AKT pathway and expression of Foxp3 from 18.6% to 26.6...Continue Reading

References

Jul 1, 2008·The International Journal of Biochemistry & Cell Biology·Stefano FaloneFernanda Amicarelli
Dec 31, 2008·Nature Reviews. Immunology·Jochen HuehnAlf Hamann
Mar 13, 2009·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Zoreh Davanipour, Eugene Sobel
Nov 17, 2009·Journal of Epidemiology·Tomohiro SaitoMichinori Kabuto
Feb 24, 2010·Biological Trace Element Research·Mehmet Zulkuf AkdagAbdullah Taşkin
May 1, 2010·Reviews on Environmental Health·David O Carpenter
Jan 15, 2013·Molecular and Cellular Biochemistry·Mahandranauth A ChetramCimona V Hinton
Jun 26, 2013·Biochemical and Biophysical Research Communications·Ju Mei LiuXiao Qian Chen
Aug 3, 2013·Free Radical Research·A M TormosJ Sastre
Jan 15, 2014·Current Opinion in Immunology·Hiroyoshi Nishikawa, Shimon Sakaguchi
Dec 3, 2014·The International Journal of Biochemistry & Cell Biology·Yanfeng ChenQunli Zeng

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Citations

Oct 24, 2017·International Journal of Molecular Sciences·Huizhen Wang, Xin Zhang
Jul 1, 2020·Advanced Science·Jiaojiao WuYu Cheng
Jun 15, 2021·Environmental Research·Piotr PiszczekJolanta Kaszuba-Zwoińska

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