Extrinsic neural innervation mediates absorption of water and electrolytes in canine proximal colon in vivo

The Journal of Surgical Research
M L KendrickM G Sarr

Abstract

Extrinsic innervation mediates a proabsorptive effect in small intestine. Our aim was to determine whether extrinsic neural input modulates similar effects in the proximal colon in vivo. Ten adult dogs underwent enteric isolation of a 50-cm proximal colon loop; five each were randomized to undergo extrinsic denervation (Ext Den) of the isolated colonic segment or to serve as neurally innervated controls. After recovery, a 38 degrees C electrolyte solution (Na(+) 125 meq/L, K(+) 9 meq/L, Cl(-) 75 meq/L, HC03(-) 65 meq/L) was infused at 4 ml/min into the segment. Effluent was collected in 30-min intervals for 2 h after achieving steady state (determined by 14C nonabsorbable marker recovery); four studies were conducted at 1 and 12 weeks postoperatively. Net flux of H20, Na(+), K(+), and Cl(-) was determined. Colon morphometry was evaluated at 0 and 14 weeks. Data are presented as mean +/- SEM. Unpaired t test was applied for comparisons. Net absorptive flux of H20 (microL/min/cm) was decreased in Ext Den vs controls at 1 week (4.40 +/- 0.63 vs 7.92 +/- 0.92, P = 0.03) but was not different at 12 weeks (4.70 +/- 1.20 vs 5.97 +/- 0.69; P > 0.05). Na(+) and Cl(-) followed the trends in H20 absorption (P < or = 0.05). Crypt depth (mi...Continue Reading

References

Nov 1, 1977·The Journal of Physiology·J G BrowningP A Sanford
Sep 1, 1991·The Journal of Surgical Research·M G SarrA M Walters
Oct 1, 1990·Diseases of the Colon and Rectum·W E Roediger
Mar 27, 1994·Transplantation·S TodoA J Demetris
Sep 1, 1995·Annals of Surgery·S TodoT E Starzl

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Citations

Feb 1, 2019·Veterinary Ophthalmology·Jiucheng HeHaydee E P Bazan
Sep 21, 2011·Veterinary Ophthalmology·Anja WelihozkiyChristopher G Pirie
Jun 19, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Anna ForsbyNeena K Tierney
Dec 19, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Thang Luong PhamHaydee E P Bazan
Aug 7, 2017·Clinical and Translational Medicine·Tyler G Rowsey, Dimitrios Karamichos
May 19, 2012·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Mitra TavakoliRayaz A Malik
Mar 4, 2003·Journal of Applied Physiology·Lian WangDonovan B Yeates

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